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Journal Articles (*Equal Contribution / #Corresponding Author)
Last update:
17th March 2023

2023

79. Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment
Widodo SS*, Dinevska M*, Cuzcano L, Papanicolaou M, Cox TR, Stylli SS, Mantamadiotis T
Advance in Cancer Biology & Metastasis
(2023) [doi: 10.1016/j.adcanc.2023.100096]
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78. Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
Hastings JF*, Latham SL*, Kamali A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Pantarelli C, Cadell AL, O’Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR
Science Advances
(2023) [doi: 10.1126/sciadv.abp8314]
PubMed | HTML

2022

77. Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma
Parker AL#, Bowman E, Zingone A, Ryan BM, Cooper WA, Kohonen-Corish M, Harris CC, Cox TR#
Genome Medicine
(2022) [doi: 10.1186/s13073-022-01127-6]
PubMed | HTML

76. Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues
Jamaluddin MFB, Ghosh A, Ingle A, Mohammed R, Ali A, Bahrami M, Kaiko G, Gibb Z, Filipe EC, Cox TR, Boulton A, O’Sullivan R, Ius Y, Karakoti A, Vinu A, Naha P, Jaaback K, Bansal V, Tanwar P
Proc. Natl Acad. Sci. USA (PNAS)
(2022) [doi: 10.1073/pnas.2208040119]
PubMed | HTML

75. Dynamic dentin: A quantitative microscopic assessment of age and spatial changes to matrix architecture, peritubular dentin, and collagens types I and III
Weerakoon AT, Condon N, Cox TR, Sexton C, Cooper C, Meyers IA, Thompson D, Ford PJ, Roy S, Symons AL
Journal of Structural Biology
(2022) [doi: 10.1016/j.jsb.2022.107899]
PubMed | HTML

74. Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
Papanicolaou M*, Parker AL*, Yam M, Filipe EC, Wu SZ, Chitty JL, Wyllie K, Tran E, Mok E, Nadalini A, Skhinas JN, Lucas MC, Herrmann D, Nobis M, Pereira BA, Law AMK, Castillo L, Murphy KJ, Zaratzian A, Hastings JF, Croucher DR, Lim E, Oliver BG, Valdes Mora F, Parker BL, Gallego-Ortega D, Swarbrick A, O’Toole S, Timpson P#, Cox TR#
Nature Communications
(2022) [doi: 10.1038/s41467-022-32255-7]
PubMed | HTML | PDF

73. ALTEN: A high-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo
Law AMK, Chen J, Colio-Sanguino Y, Rodriguez de la Fuente L, Fang G, Grimes SM, Lu H, Huang RJ, Boyle ST, Venhuizen J, Castillo L, Tavakoli J, Skhinas JN, Millar EKA, Beretov J, Rossello FJ, Tipper JL, Cox TR, Martelotto L, Jin D, Valdes-Mora F, Ji HP, Gallego-Ortega D
Advanced Science
(2022) [doi: 10.1002/advs.202103332]
PubMed | HTML | PDF

2021

72. Micromechanical characterisation of 3D bioprinted neural cell models using Brillouin microspectroscopy
Alsadat Rad M, Mahmodi H, Filipe EC, Cox TR, Kabakova I, Tipper JL
Bioprinting
(2021) [doi: 10.1016/j.bprint.2021.e00179]
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71. Pirfenidone Reduces Epithelial–Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts
Aboulkheyr Es H, Cox TR, Sarafraz-Yazdi E, Thiery JP, Warkiani ME
Cancers
(2021) [doi: 10.3390/cancers13205118]
PubMed | HTML

70. Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XE, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, Australian Pancreatic Genome Initiative (APGI), Australian Pancreatic Cancer Matrix Atlas (APMA), Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz J, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic, M, Herrmann D, Timpson P
Science Advances
(2021) [doi: 10.1126/sciadv.abh0363]
PubMed | HTML

69. Towards engineering heart tissues from bioprinted cardiac spheroids
Polonchuk L, Surija L, Lee MH, Sharma P, Ming CLC, Richter F, Ben-Sefer E, Alsadat Rad M, Sarmast HMS, Al Shamery W, Tran HA, Vettori L, Haeusermann F, Filipe EC, Rnjak-Kovacina J, Cox TR, Tipper J, Kabakova I, Gentile C
Biofabrication
(2021) [doi: 10.1088/1758-5090/ac14ca]
PubMed | HTML

68. Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP
Guo G*, Papanicolaou M*, Demarais NJ, Wang Z, Schey KL, Timpson P, Cox TR#, Grey AC#
Nature Communications
(2021) [doi: 10.1038/s41467-021-23461-w]
PubMed | HTML | PDF

67. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition
Sharbeen G, McCarroll JA, Akerman A, Kopecky C, Youkhana J, Kokkinos J, Holst J , Boyer C, Erkan M, Goldstein D, Timpson P, Cox TR, Pereira BA, Chitty JL, Fey SK, Najumudeen AK, Campbell AD, Sansom OJ, Ignacio RMC, Naim S, Liu J, Russia N, Lee J, Chou A, Johns A, Gill AJ, Gonzales-Aloy E, Gebski V, Guan YF, Pajic M, Turner N, Apte MV, Davis TP, Morton JP, Haghighi KS, Kasparian J, McLean BJ, Setargew YFI, Australian Pancreatic Cancer Genome Initiative (APGI), Phillips PA
Cancer Research
(2021) [doi: 10.1158/0008-5472.CAN-20-2496]
PubMed | HTML | PDF

66. Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype
Valdés-Mora F, Salomon R, Gloss BS, Law AMK, Venhuizen J, Castillo L, Murphy KJ, Magenau A, Papanicolaou M, Rodriguez de la Fuente L, Roden DL, Colino-Sanguino Y, Kikhtyak Z, Farbehi N, Conway JRW, Sikta N, Oakes SR, Cox TR, O’Donoghue SI, Timpson P, Ormandy CJ, Gallego-Ortega D
Cell Reports
(2021) [doi: 10.1016/j.celrep.2021.108945 ]
PubMed | HTML

65. The Matrix in Cancer
Cox TR
#
Nature Reviews Cancer
(2021) [doi: 10.1038/s41568-020-00329-7]
PubMed | HTML | PDF (read-only)

64. Inhibitor of Differentiation4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB
Holliday H, Roden D, Junankar S, Wu SZ, Baker LA, Krisp C, Chan CL, McFarland A, Skhinas JN, Cox TR, Pal B, Huntington ND, Ormandy CJ, Carroll JS, Visvader J, Molloy MP and Swarbrick A
iScience
(2021) [doi: 10.1016/j.isci.2021.102072]
PubMed | HTML (Open Access) |PDF

63. Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours
Setargew YFI*, Wyllie K*, Grant RD, Chitty JL# and Cox TR#
Cancers
(2021) [doi: 10.3390/cancers13030491]
PubMed | HTML (Open Access) |PDF

2020

62. The Role of the ECM in Lung Cancer Dormancy and Outgrowth
Parker AL*# and Cox TR*#
Frontiers in Oncology
(2020) [doi: 10.3389/fonc.2020.01766]
PubMed | HTML (Open Access) |PDF

61. Stromal cell diversity associated with immune evasion in human triple-negative breast cancer
Wu SZ, Roden DL, Wang C, Holliday H, Harvey K, Cazet AS, Murphy KJ, Pereira B, Al-Eryani G, Bartonicek N, Hou R, Torpy JR, Junankar S, Chan CL, Lam CE, Hui MN, Gluch L, Beith J, Parker A, Robbins E, Segara S, Mak C, Cooper C, Warrier S, Forrest A, Powell J, O’Toole S, Cox TR, Timpson P, Lim E, Lui XS, Swarbrick A
EMBO
(2020) [doi: 10.15252/embj.2019104063]
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60. Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo
Michael P, Lam YT, Filipe EC, Tan RP, Chan AHP, Lee BSL, Feng N, Hung J, Cox TR, Santos M, Wise SG
Scientific Reports
(2020) [doi: 10.1038/s41598-020-69591-x]
PubMed | HTML (Open Access) | PDF

59. Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan
Elgundi Z, Papanicolaou M, Major G, Cox TR, Melrose J, Whitelock JM, Farrugia BL
Frontiers in Oncology
(2020) [doi: 10.3389/fonc.2019.01482]
PubMed | HTML (Open Access) | PDF

2019

58. Targeting the lysyl oxidases in tumour desmoplasia
Chitty JL, Setargew YFI, Cox TR#
Biochemical Society Transactions (2019) [doi: 10.1042/BST20190098]
PubMed | HTML | PDF

57. CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer
Pereira BA*, Vennin C*, Papanicolaou M, Chambers CR, Herrmann D, Morton JP, Cox TR#, Timpson P#
Trends in Cancer (2019) [doi: 10.1016/j.trecan.2019.09.010]
PubMed | HTML (Open Access) | PDF

56. CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin C, Mélénec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W, Australian Pancreatic cancer Genome Initiative (APGI), Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR#, Timpson P#
Nature Communications (2019) [doi: 10.1038/s41467-019-10968-6]
PubMed | HTML (Open Access) | PDF

55. The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development
Chitty JL, Skhinas JN, Filipe EC, Wang, S, Rodriguez Cupello C, Grant RD, Yam M, Papanicoloau M, Major G, Zaratzian A, Da Silva AM, Tayao M, Vennin C, Timpson P, Madsen CD#, Cox TR#
Cancer Reports
(2019) [doi: 10.1002/cnr2.1209]
PubMed | HTML (Open Access) | PDF

54. The importance of developing therapies targeting the biological spectrum of metastatic disease.
Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA
Clinical & Experimental Metastasis (2019) [doi: 10.1007/s10585-019-09972-3]
PubMed | HTML

53. LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity
Zeltz C*, Pasko E*, Cox TR, Navab R, Tsao MS
Cancers (2019) [doi: 10.3390/cancers11050705]
PubMed | HTML (Open Access) | PDF

52. Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment.
Nguyen EV*, Pereira BA*, Lawrence MG, Ma X, Rebello RJ, Chan H, Niranjan B, Wu Y, Ellem S, Guan X, Wu J, Skhinas JN, Cox TR, Risbridger GP, Taylor RA, Lister NL, Daly R.
Molecular & Cellular Proteomics (2019) [doi: 10.1074/mcp.RA119.001496]
PubMed | HTML

51. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
Kennedy SP*, Han JZR*, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O’Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR
Breast Cancer Research (2019) [doi: 10.1186/s13058-019-1127-y]
PubMed | HTML

50. The extracellular matrix as a key regulator of intracellular signalling networks
Hastings JF*, Skhinas JN*, Fey D, Croucher DR#, Cox TR#
British Journal of Pharmacology (2019) [doi: 10.1111/bph.14195]
PubMed | HTML | PDF

2018

49. Cancer cell ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Wullkopf L, West AV, Leijnse N, Cox TR, Madsen CD, Oddershede LB, Erler JT
Molecular Biology of the Cell (2018) [doi: 10.1091/mbc.E18-05-0319]
PubMed | HTML

48. Recent advances in understanding the complexities of metastasis
Chitty JL*, Filipe EC*, Lucas MC, Herrmann D, Cox TR#, Timpson P#
F1000Research (2018) [doi: 10.12688/f1000research.15064.1]
PubMed | HTML | PDF | Download Fig. 1 (Hi-Res)

47. Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
Cazet AS*, Hui MN*, Elsworth BL, Wu SZ, Roden D, Chan CL, Skhinas JN, Collot R, Yang J, Harvey K, Johan MZ, Cooper C, Nair R, Herrmann D, McFarland A, Deng N, Ruiz-Borrego M, Rojo F, Trigo JM, Bezares S, Caballero R, Lim E, Timpson P, O’Toole S, Watkins ND,
Cox TR, Samuel MS, Martín M, Swarbrick A
Nature Communications (2018) [doi: 10.1038/s41467-018-05220-6]
PubMed | HTML | PDF

46. Tumor endothelial marker 8 promotes cancer progression and metastasis.
Høye AM*, Tolstrup SD*, Horton ER, Nicolau M, Frost H, Woo JH, Mauldin JP, Frankel AE, Cox TR, Erler JT
Oncotarget (2018) [doi: 10.18632/oncotarget.25734]
PubMed | HTML | PDF

45. Removing physiological motion from intravital and clinical functional imaging data
Warren SC, Nobis M, Magenau A, Mohammed YH, Herrmann D, Moran I, Vennin C, Conway JRW, Melenec P, Cox TR, Wang Y, Morton JP, Welch, HCE, Strathdee D, Anderson KI, Phan TG, Roberts MS, Timpson P
eLife (2018) [doi: 10.7554/eLife.35800]
PubMed | HTML | PDF | Download Galene

44. Charting the unexplored extracellular matrix in cancer
Filipe EC*, Chitty JL*, Cox TR#
International Journal of Experimental Pathology (2018) [doi: 10.1111/iep.12269]
PubMed | HTML | PDF

43. Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse
Nobis M, Herrmann D, Warren SC, Cox TR, Anderson KI, Timpson P
Small GTPases (2018) [doi: 10.1080/21541248.2018.1438024]
PubMed | HTML| Request a Copy

42. Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer
Vennin C, Murphy KJ, Morton JP, Cox TR, Pajic M, Timpson P
Gastroenterology (2018) [doi: 10.1053/j.gastro.2017.11.280]
PubMed | HTML | Request a Copy

41. Proteomic Characterisation of Caenorhabditis elegans Larval Development
Xia T*, Horton ER*, Salcini AE, Pocock R, Cox TR#, Erler JT#
Proteomics (2018) [doi: 10.1002/pmic.201700238]
PubMed | HTML

40. Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Cox TR
#, Erler JT and Rumney RMH#
Calcified Tissue International (2018) [doi: 10.1007/s00223-017-0352-6]
PubMed | HTML

39. Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example
Fingleton B, Lange K, Caldwell B, Bankaitis KV, Board of the Metastasis Research Society (Kang Y, Yu D, Aguirre-Ghiso J, Cox TR, Erler JT, Gelman IH, Hurst DR, Kato Y, Lynch CC, Price JT, Samant RS, Sleeman J, Stein U, Zijlstra A)
Clinical & Experimental Metastasis (2018) [doi: 10.1007/s10585-017-9872-8]
PubMed | HTML

38. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Chou A, Froio D, Nagrial AN, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ, Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M
Gut (2018) [doi: 10.1136/gutjnl-2017-315144]
PubMed | HTML

37. The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.
Skhinas JN and Cox TR#
Cell Adhesion & Migration
(2018) [doi: 10.1080/19336918.2017.1405208]
PubMed | HTML

2017

36. Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology
Conway JRW, Vennin C, Cazet AS, Herrmann D, Murphy KJ, Warren SC, Wullkopf L, Boulghourjian A, Zaratzian A, Da Silva AM, Pajic M, Morton JP, Cox TR#, Timpson P#
Scientific Reports (2017) [doi: 10.1038/s41598-017-17177-5]
PubMed | HTML

35. Transient targeting of the pancreatic cancer stroma as a ‘fine-tuned’ anti-tumor and anti-metastatic therapy
Vennin C, Cox TR, Pajic M, Timpson P
Oncotarget (2017) [doi: 10.18632/oncotarget.21468]
PubMed | HTML

34. Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
Koplev S*, Longden J*, Ferkinghoff-Borg J*, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R
Cell Reports (2017) [doi: 10.1016/j.celrep.2017.08.095]
PubMed | HTML

33. ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix
Mayorca-Guiliani AE*, Madsen CD*, Cox TR*, Horton ER, Venning FA, Erler JT
Nature Medicine (2017) [doi: 10.1038/nm.4352]
PubMed | HTML | PDF

32. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Vennin C*, Chin VT*, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec A, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Australian Pancreatic Cancer Genome Initiative (APGI), Evans TRJ, Anderson KI, Gray ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.
Science Translational Medicine (2017) [doi: 10.1126/scitranslmed.aai8504]
PubMed | HTML

31. Relative Stiffness Measurements of Tumour Tissues by Shear Rheology
Madsen CD# and Cox TR#
Bio-protocol (2017) [doi: 10.21769/BioProtoc.2265]
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30. Pre-metastatic niches: organ-specific homes for metastases
Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissel MJ, Cox TR, Giaccia A, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.
Nature Reviews Cancer (2017) [doi: 10.1038/nrc.2017.6]
PubMed | HTML

29. Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang J, Lucas M, Leonte L, Garcia-Montolio M, Babloo Singh L, Findlay A, Deodhar M, Foot J, Jarolimek W, Timpson P, Erler JT#, Cox TR#
Oncotarget
(2017) [doi: 10.18632/oncotarget.15257]
PubMed | HTML

28. Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight
Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC
PLoS ONE (2017) [doi: 10.1371/journal.pone.0169664]
PubMed | HTML

27. Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro
Cox TR# and Madsen CD#
Bio-protocol (2017) [doi: 10.21769/BioProtoc.2101]
HTML

26. Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC
Scientific Reports (2017) [doi: 10.1038/s41598-017-00144-5]
PubMed | HTML

2016

25. The Role of Lysyl Oxidase, the Extracellular Matrix and the Pre-Metastatic Niche in Bone Metastasis
Gartland A, Erler JT and Cox TR
Journal of Bone Oncology (2016) [doi: 10.1016/j.jbo.2016.04.001]
PubMed | HTML

24. Fibrosis and Cancer: Partners in Crime or Opposing Forces?
Cox TR
# and Erler JT#
Trends In Cancer (2016) [doi: 10.1016/j.trecan.2016.05.004]
HTML

23. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients
Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF
Oncotarget (2016) [doi: 10.18632/oncotarget.9623]
PubMed | HTML (Open Access)

22. Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis
Cox TR
#, Gartland A, Erler JT
Cancer Research (2016) [doi: 10.1158/0008-5472.CAN-15-2306]
PubMed | HTML | PDF

2015

21. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism
Cox TR
*#, Schoof EM*, Gartland A, Erler JT, Linding R#
Data In Brief (2015) [doi: 10.1016/j.dib.2015.09.039]
PubMed | HTML | PDF (Open Access)

20. Kinome-wide Decoding of Network Attacking Mutations Rewiring Cancer
Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R
Cell (2015) [doi: 10.1016/j.cell.2015.08.056]
PubMed | HTML | PDF (Open Access)

19. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.
EMBO Reports (2015) [doi: 10.15252/embr.201540107]
PubMed | HTML | PDF (Open Access)

18. AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
Rodriguez‐Teja M, Gronau JH, Breit C,  Zhang Y, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J
The Journal of Pathology (2015) [doi: 10.1002/path.4485]
PubMed | HTML | PDF

2014

17. Molecular pathways: connecting fibrosis and solid tumor metastasis
Cox TR# and Erler JT#
Clinical Cancer Research (2014) [doi: 10.1158/1078-0432.CCR-13-1059]
PubMed | HTML | PDF

16. Lysyl oxidase in colorectal cancer
Cox TR and Erler JT
American Journal of Physiology – Gastrointestinal and Liver Physiology (2014) [doi: ]
PubMed | HTML | PDF

15. Fibrosis, cancer and the premetastatic niche
Cox TR# and Erler JT#
Breast Cancer Management (2014) doi: 10.2217/bmt.14.36
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2013

14. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT
Breast Cancer Research (2013) [doi: 10.1186/bcr3461]
PubMed | HTML | PDF

13. The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis
Cox TR and Erler JT
Journal of Carcinogenesis & Mutagenesis (2013) [doi: 10.4172/2157-2518.S13-001]
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12. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT
Cancer Research (2013) [doi: ]
PubMed | HTML | PDF

11. Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
Baker AM, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, Reynolds A, Cox TR, Erler JT
Cancer Research (2013) [doi: ]
PubMed | HTML | PDF

10. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
Baker AM, Lang G, Bird D, Cox TR#, Erler JT#
Oncogene (2013) [doi: 10.1038/onc.2012.202]
PubMed | HTML | PDF

2012

9. Network biology and the 3-Dimensional tumor micro-environment: personalizing medicine for the future
Cox TR and Erler JT
Tumor Microenvironment and Therapy (2012) [doi: 10.2478/tumor-2012-0002]
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8. The rationale for targeting the LOX family in cancer
Barker HE*, Cox TR* and Erler JT
Nature Reviews Cancer (2012) [doi: 10.1038/nrc3319]
PubMed | HTML | PDF

7. The pre-metastatic niche: is metastasis random?
Cox TR, Gartland A and  Erler JT
BoneKEy Reports (2012) [doi: 10.1038/bonekey.2012.80]
PubMed | HTML | PDF

2011

6. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Cox TR and Erler JT
Disease Models and Mechanisms (2011) []
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5. The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT
Journal of the National Cancer Institute (2011) [doi: 10.1093/jnci/djq569]
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4. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT
Cancer Research (2011) [doi: ]
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2010

3. Tissue section AFM: In situ ultrastructural imaging of native biomolecules
Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ
Matrix Biology (2010) [doi: 10.1016/j.matbio.2010.01.008]
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2009

2. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Erler JT*, Bennewith KL*, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ
Cancer Cell (2009) [doi: 10.1016/j.ccr.2008.11.012]
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2008

1. Lamin A/C is a risk biomarker in colorectal cancer
Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A, Hutchison CJ
PLOSOne (2008) [doi: 10.1371/journal.pone.0002988]
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Patents

A bioinformatics engine for automated annotation and visualisation of high-resolution spatial proteomics mass spectrometry imaging data
Garvan Institute of Medical Research (2021)
Inventors: Guo G, Papanicoloau M, Cox TR, Grey AC
PCT/AU2021/030363

ALTEN (Alginate-based Tissue Encapsulation): a method for encapsulating animal tissue in an alginate-based hydrogel for drug-screening in the context of personalised cancer therapies
Garvan Institute of Medical Research (2020)
Inventors: Law A, Skhinas JN, Cox TR, Gallego-Ortega D
PCT/AU2020/050129

Methods for determining a prognosis of colorectal cancer
University of Durham (2007)
Inventors: Cox TR, De Bruin A, Hutchison CJ, Przyborski S, Van Engeland M, Wilson R

WO2007148095 A8


Book Chapters

5. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments
Ramchandani D, El Rayes TP, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment (Second Edition)
Akslen, LA., Watnick, RS. (Eds.)
Springer International Publishing (2022)
ISBN 978-3-030-98949-1
doi: 10.1007/978-3-030-98950-7
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4. In Vitro 3D Models of Tunable Stiffness
Filipe EC*, Parker AL*, Cadell AL, Major G, Croucher DR, Cox TR#
In Metastasis: Methods in Molecular Biology
Stein, U. (Ed.)
Humana Press, Springer (2021)
ISBN 978-1-0716-1350-4
doi: 10.1007/978-1-0716-1350-4_3
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3. The Extracellular Matrix (ECM)
Papanicolaou M and Cox TR#
In Encyclopedia of Molecular Pharmacology
Offermanns, S., Rosenthal, W. (Eds.)
Springer, Cham (2021)
ISBN 978-3-030-21573-6
doi: 10.1007/978-3-030-57401-7_5691
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2. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments
El Rayes T, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment (First Edition)
Akslen, LA., Watnick, RS. (Eds.)
Springer International Publishing (2017)
ISBN 978-3-319-39147-2
doi: 10.1007/978-3-319-39147-2_13
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1. Remodelling of the Extracellular Matrix: Implications for Cancer
Cox TR and Erler JT
In Cell and Molecular Biology of Breast Cancer
Schatten, H. (Ed.)
Humana Press, Springer (2013)
ISBN 978-1-62703-633-7
doi: 10.1007/978-1-62703-634-4_4
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Metrics

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