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Journal Articles (*Equal Contribution / #Corresponding Author)
Last update: 8 Jan 2020




55. Targeting the lysyl oxidases in tumour desmoplasia
Chitty JL, Setargew YFI, Cox TR#
Biochemical Society Transactions (2019) [doi: 10.1042/BST20190098]
PubMed | HTML | Read PDF

54. CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer
Pereira BA*, Vennin C*, Papanicolaou M, Chambers CR, Herrmann D, Morton JP, Cox TR#, Timpson P#
Trends in Cancer (2019) [doi: 10.1016/j.trecan.2019.09.010]

53. CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin C, Mélénec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W, (APGI) Australian Pancreatic cancer Genome Initiative, Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR#, Timpson P#
Nature Communications (2019) [doi: 10.1038/s41467-019-10968-6]
PubMed | HTML (Open Access) | Download PDF

52. The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development
Chitty JL, Skhinas JN, Filipe EC, Wang, S, Rodriguez Cupello C, Grant RD, Yam M, Papanicoloau M, Major G, Zaratzian A, Da Silva AM, Tayao M, Vennin C, Timpson P, Madsen CD#, Cox TR#
Cancer Reports (2019) [doi: 10.1002/cnr2.1209]
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51. LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity
Zeltz C*, Pasko E*, Cox TR, Navab R, Tsao MS
Cancers (2019) [doi: 10.3390/cancers11050705]
PubMed | HTML (Open Access) | Download PDF

50. Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment.
Nguyen EV*, Pereira BA*, Lawrence MG, Ma X, Rebello RJ, Chan H, Niranjan B, Wu Y, Ellem S, Guan X, Wu J, Skhinas JN, Cox TR, Risbridger GP, Taylor RA, Lister NL, Daly R.
Molecular & Cellular Proteomics (2019) [doi: 10.1074/mcp.RA119.001496]
PubMed | HTML

49. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
Kennedy SP*, Han JZR*, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O’Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR
Breast Cancer Research (2019) [doi: 10.1186/s13058-019-1127-y]
PubMed | HTML

48. The extracellular matrix as a key regulator of intracellular signalling networks
Hastings JF*, Skhinas JN*, Fey D, Croucher DR#, Cox TR#
British Journal of Pharmacology (2019) [doi: 10.1111/bph.14195]
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47. Cancer cell ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Wullkopf L, West AV, Leijnse N, Cox TR, Madsen CD, Oddershede LB, Erler JT
Molecular Biology of the Cell (2018) [doi: 10.1091/mbc.E18-05-0319]
PubMed | HTML

46. Recent advances in understanding the complexities of metastasis
Chitty JL*, Filipe EC*, Lucas MC, Herrmann D, Cox TR#, Timpson P#
F1000Research (2018) [doi: 10.12688/f1000research.15064.1]
PubMed | HTML | Download PDF | Download Fig. 1 (Hi-Res)

45. Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
Cazet AS*, Hui MN*, Elsworth BL, Wu SZ, Roden D, Chan CL, Skhinas JN, Collot R, Yang J, Harvey K, Johan MZ, Cooper C, Nair R, Herrmann D, McFarland A, Deng N, Ruiz-Borrego M, Rojo F, Trigo JM, Bezares S, Caballero R, Lim E, Timpson P, O’Toole S, DN Watkins, Cox TR, Samuel MS, Martín M, Swarbrick A
Nature Communications (2018) [doi: 10.1038/s41467-018-05220-6]
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44. Tumor endothelial marker 8 promotes cancer progression and metastasis.
Høye AM*, Tolstrup SD*, Horton ER, Nicolau M, Frost H, Woo JH, Mauldin JP, Frankel AE, Cox TR, Erler JT
Oncotarget (2018) [doi: 10.18632/oncotarget.25734]
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43. Removing physiological motion from intravital and clinical functional imaging data
Warren SC, Nobis M, Magenau A, Mohammed YH, Herrmann D, Moran I, Vennin C, Conway JRW, Melenec P, Cox TR, Wang Y, Morton JP, Welch, HCE, Strathdee D, Anderson KI, Phan TG, Roberts MS, Timpson P
eLife (2018) [doi: 10.7554/eLife.35800]
PubMedHTML | Download PDF | Download Galene

42. Charting the unexplored extracellular matrix in cancer
Filipe EC*, Chitty JL*, Cox TR#
International Journal of Experimental Pathology (2018) [doi: 10.1111/iep.12269]
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41. Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse
Nobis M, Herrmann D, Warren SC, Cox TR, Anderson KI, Timpson P
Small GTPases (2018) [doi: 10.1080/21541248.2018.1438024]
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40. Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer
Vennin C, Murphy KJ, Morton JP, Cox TR, Pajic M, Timpson P
Gastroenterology (2018) [doi: 10.1053/j.gastro.2017.11.280]
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39. Proteomic Characterisation of Caenorhabditis elegans Larval Development
Xia T*, Horton ER*, Salcini AE, Pocock R, Cox TR#, Erler JT#
Proteomics (2018) [doi: 10.1002/pmic.201700238]
PubMed | HTML

38. Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Cox TR#, Erler JT and Rumney RMH#
Calcified Tissue International (2018) [doi: 10.1007/s00223-017-0352-6]
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37. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Chou A, Froio D, Nagrial AN, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ, Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M
Gut (2018) [doi: 10.1136/gutjnl-2017-315144]
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36. The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.
Skhinas JN, Cox TR#
Cell Adhesion & Migration (2018) [doi: 10.1080/19336918.2017.1405208]
PubMed | HTML


35. Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology
Conway JRW, Vennin C, Cazet AS, Herrmann D, Murphy KJ, Warren SC, Wullkopf L, Boulghourjian A, Zaratzian A, Da Silva AM, Pajic M, Morton JP, Cox TR#, Timpson P#
Scientific Reports (2017) [doi: 10.1038/s41598-017-17177-5]
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34. Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
Koplev S*, Longden J*,  Ferkinghoff-Borg J*, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R
Cell Reports (2017) [doi: 10.1016/j.celrep.2017.08.095]
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33. ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix
Mayorca-Guiliani AE*, Madsen CD*, Cox TR*, Horton ER, Venning FA, Erler JT
Nature Medicine (2017) [doi: 10.1038/nm.4352]
PubMed | HTML | PDF

32. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Vennin C*, Chin VT*, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec A, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Australian Pancreatic Cancer Genome Initiative (APGI), Evans TRJ, Anderson KI, Gray ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.
Science Translational Medicine (2017) [doi: 10.1126/scitranslmed.aai8504]
PubMed | HTML

31. Relative Stiffness Measurements of Tumour Tissues by Shear Rheology
Madsen CD# and Cox TR#
Bio-protocol (2017) [doi: 10.21769/BioProtoc.2265]

30. Pre-metastatic niches: organ-specific  homes for metastases
Peinado H*, Zhang H*, Matei IR*, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissel MJ, Cox TR, Giaccia A, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.
Nature Reviews Cancer (2017) [doi: 10.1038/nrc.2017.6]
PubMed | HTML

29. Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang J, Lucas M, Leonte L, Garcia-Montolio M, Babloo Singh L, Findlay A, Deodhar M, Foot J, Jarolimek W, Timpson P, Erler JT#, Cox TR#
(2017) [doi: 10.18632/oncotarget.15257]
PubMed | HTML

28. Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight
Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC
PLoS ONE (2017) [doi: 10.1371/journal.pone.0169664]
PubMed | HTML

27.  Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro
Cox TR# and Madsen CD#
Bio-protocol (2017) [doi: 10.21769/BioProtoc.2101]

26. Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC
Scientific Reports (2017) [doi: 10.1038/s41598-017-00144-5]
PubMed | HTML


25. The Role of Lysyl Oxidase, the Extracellular Matrix and the Pre-Metastatic Niche in Bone Metastasis
Gartland A, Erler JT and Cox TR
Journal of Bone Oncology (2016) [doi: 10.1016/j.jbo.2016.04.001]
PubMed | HTML

24. Fibrosis and Cancer: Partners in Crime or Opposing Forces?
Cox TR# and Erler JT#
Trends In Cancer (2016) [doi: 10.1016/j.trecan.2016.05.004]

23. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients
Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF
Oncotarget (2016) [doi: 10.18632/oncotarget.9623]
PubMed | HTML (Open Access)

22. Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis
Cox TR#, Gartland A, Erler JT
Cancer Research (2016) [doi: 10.1158/0008-5472.CAN-15-2306]
PubMed | HTML | PDF


21. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism
Cox TR#*, Schoof EM*, Gartland A, Erler JT, Linding R#
Data In Brief (2015) [doi: 10.1016/j.dib.2015.09.039]
PubMed | HTML | PDF (Open Access)

20. Kinome-wide Decoding of Network Attacking Mutations Rewiring Cancer
Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R
Cell (2015) [doi: 10.1016/j.cell.2015.08.056]
PubMed | HTML | PDF (Open Access)

19. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.
EMBO Reports (2015) [doi: 10.15252/embr.201540107]
PubMed | HTML | PDF (Open Access)

18. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird, D, Ab Latif N, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT.
Nature (2015) [doi: 10.1038/nature14492]
PubMed | HTML | PDF (read-only) | HTML (Open Access on PMC)

17. AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
Rodriguez‐Teja M, Gronau JH, Breit C,  Zhang Y, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J
The Journal of Pathology (2015) [doi: 10.1002/path.4485]
PubMed | HTML | PDF


16. Molecular pathways: connecting fibrosis and solid tumor metastasis
Cox TR# and Erler JT#
Clinical Cancer Research (2014) [doi: 10.1158/1078-0432.CCR-13-1059]
PubMed | HTML | PDF

15. Lysyl oxidase in colorectal cancer
Cox TR and Erler JT
American Journal of Physiology – Gastrointestinal and Liver Physiology (2014) [doi: ]
PubMed | HTML | PDF


14. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT
Breast Cancer Research (2013) [doi: 10.1186/bcr3461]
PubMed | HTML | PDF

13. The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis
Cox TR and Erler JT
Journal of Carcinogenesis & Mutagenesis (2013) [doi: 10.4172/2157-2518.S13-001]

12. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT
Cancer Research (2013) [doi: ]
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11. Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
Baker AM, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, Reynolds AR, Cox TR, Erler JT
Cancer Research (2013) [doi: ]
PubMed | HTML | PDF

10. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
Baker AM, Lang G, Bird D, Cox TR#, Erler JT#
Oncogene (2013) [doi: 10.1038/onc.2012.202]
PubMed | HTML | PDF


9. Network biology and the 3-Dimensional tumor micro-environment: personalizing medicine for the future
Cox TR and Erler JT
Tumor Microenvironment and Therapy (2012) [doi: 10.2478/tumor-2012-0002]

8. The rationale for targeting the LOX family in cancer
Barker HE*, Cox TR* and Erler JT
Nature Reviews Cancer (2012) [doi: 10.1038/nrc3319]
PubMed | HTML | PDF

7. The pre-metastatic niche: is metastasis random?
Cox TR, Gartland A and  Erler JT
BoneKEy Reports (2012) [doi: 10.1038/bonekey.2012.80]
PubMed | HTML | PDF


6. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Cox TR and Erler JT
Disease Models and Mechanisms (2011) []
PubMed | HTML | PDF

5. The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT
Journal of the National Cancer Institute (2011) [doi: 10.1093/jnci/djq569]
PubMed | HTML | PDF

4. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT
Cancer Research (2011) [doi: ]
PubMed | HTML | PDF


3. Tissue section AFM: In situ ultrastructural imaging of native biomolecules
Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ
Matrix Biology (2010) [doi: 10.1016/j.matbio.2010.01.008]
PubMed | HTML | PDF


2. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Erler JT*, Bennewith KL*, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ
Cancer Cell (2009) [doi: 10.1016/j.ccr.2008.11.012]
PubMed | HTML | PDF


1. Lamin A/C is a risk biomarker in colorectal cancer
Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A, Hutchison CJ
PLOSOne (2008) [doi: 10.1371/journal.pone.0002988]
PubMed | HTML | PDF


Methods for determining a prognosis of colorectal cancer. 
University of Durham (2007)
Inventors: Cox TR, De Bruin A, Hutchison CJ, Przyborski S, Van Engeland M, Wilson R

WO2007148095 A8

Invited Editorials

6. The importance of developing therapies targeting the biological spectrum of metastatic disease.
Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA; Board Members of the Metastasis Research Society.
Clinical & Experimental Metastasis (2019) [doi: 10.1007/s10585-019-09972-3]
PubMed | HTML

5. Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis
Beadnell T, Borriello L, Christenson J, Fornetti J, Guldner I, Hanna A, Kyjacova L, Marinak-Whately K, de Melo Martins PC, Rotinen M, Te Boekhorst V, Cox TR#
Clinical & Experimental Metastasis (2019) [doi: 10.1007/s10585-018-09953-y]
PubMed | HTML

4. Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example
Fingleton B, Lange K, Caldwell B, Bankaitis KV, Board of the Metastasis Research Society (Kang Y, Yu D, Aguirre-Ghiso J, Cox TR, Erler JT, Gelman IH, Hurst DR, Kato Y, Lynch CC, Price JT, Samant RS, Sleeman J, Stein U, Zijlstra A)
Clinical & Experimental Metastasis (2018) [doi: 10.1007/s10585-017-9872-8]
PubMed | HTML

3. Transient targeting of the pancreatic cancer stroma as a ‘fine-tuned’ anti-tumor and anti-metastatic therapy
Vennin C, Cox TR, Pajic M, Timpson P
Oncotarget (2017) [doi: 10.18632/oncotarget.21468]
PubMed | HTML

2. Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis
Bankaitis K, Borriello L, Cox TR, Lynch C, Zijlstra A, Fingleton B, Gužvić M, Anderson R, Neman J
Clinical & Experimental Metastasis
(2017) [doi: 10.1007/s10585-017-9842-1]
PubMed | HTML

1. Fibrosis, cancer and the premetastatic niche
Cox TR# and Erler JT#
Breast Cancer Management (2014) doi: 10.2217/bmt.14.36

Book Chapters

2. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments
El Rayes T, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment
Akslen, LA., Watnick, RS. (Eds.)
Springer International Publishing (2017)
ISBN 978-3-319-39147-2
doi: 10.1007/978-3-319-39147-2_13

1. Remodelling of the Extracellular Matrix: Implications for Cancer
Cox TR and Erler JT
In Cell and Molecular Biology of Breast Cancer
Schatten, H. (Ed.)
Humana Press, Springer (2013)
ISBN 978-1-62703-633-7
doi: 10.1007/978-1-62703-634-4_4


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