Journal Articles | Editorials | Book Chapters | Patents | Metrics

Last update: 7th Mar 2018

Journal Articles (Peer-Reviewed)


43. Charting the unexplored extracellular matrix in cancer

Filipe EC, Chitty JL, Cox TR#
#Corresponding Author
International Journal of Experimental Pathology (2018)
doi: 10.1111/iep.12269
PubMed | HTML | Request a Copy

42. The extracellular matrix as a key regulator of intracellular signalling networks

Hastings JF, Skhinas JN, Fey D, Croucher DR#, Cox TR#
#Corresponding Authors
British Journal of Pharmacology (2018)
doi: 10.1111/bph.14195
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41. Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse

Nobis M, Herrmann D, Warren SC, Cox TR, Anderson KI, Timpson P
Small GTPases (2018)
doi: 10.1080/21541248.2018.1438024
PubMed | HTML| Request a Copy

40. Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

Vennin C, Murphy KJ, Morton JP, Cox TR, Pajic M, Timpson P
Gastroenterology (2018)
doi: 10.1053/j.gastro.2017.11.280
PubMed | HTML | Request a Copy


39. Proteomic Characterisation of Caenorhabditis elegans Larval Development

Xia T, Horton ER, Salcini AE, Pocock R, Cox TR#, Erler JT#
Proteomics (2017)
doi: 10.1002/pmic.201700238
PubMed | HTML
#Corresponding Authors

38. The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.

Skhinas JN, Cox TR#
Cell Adhesion & Migration (2017)
doi: 10.1080/19336918.2017.1405208
PubMed | HTML
#Corresponding Author

37. Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

Conway JRW, Vennin C, Cazet AS, Herrmann D, Murphy KJ, Warren SC, Wullkopf L, Boulghourjian A, Zaratzian A, Da Silva AM, Pajic M, Morton JP, Cox TR#, Timpson P#
Scientific Reports (2017)
doi: 10.1038/s41598-017-17177-5
PubMed | HTML
#Corresponding Authors

36. Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

Cox TR#, Erler JT and Rumney RMH#
Calcified Tissue International (2017)
doi: 10.1007/s00223-017-0352-6
PubMed | HTML
#Corresponding Authors

35. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

Chou A, Froio D, Nagrial AN, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ, Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M
Gut (2017)
doi: 10.1136/gutjnl-2017-315144
PubMed | HTML

34. Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments

Koplev S, Longden J,  Ferkinghoff-Borg J, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R
Cell Reports (2017)
doi: 10.1016/j.celrep.2017.08.095
PubMed | HTML

33. ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

Mayorca-Guiliani AE*, Madsen CD*, Cox TR*, Horton ER, Venning FA, Erler JT
Nature Medicine (2017)
doi: 10.1038/nm.4352
PubMed | HTML | PDF
* First authors contributed equally

32. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec A, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Australian Pancreatic Cancer Genome Initiative (APGI), Evans TRJ, Anderson KI, Gray ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.
Science Translational Medicine (2017)
doi: 10.1126/scitranslmed.aai8504
PubMed | HTML

31. Relative Stiffness Measurements of Tumour Tissues by Shear Rheology

Madsen CD# and Cox TR#
Bio-protocol (2017)
doi: 10.21769/BioProtoc.2265
#Corresponding Authors

30. Pre-metastatic niches: organ-specific  homes for metastases

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissel MJ, Cox TR, Giaccia A, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.
Nature Reviews Cancer (2017)
doi: 10.1038/nrc.2017.6
PubMed | HTML

29. Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

Chang J, Lucas M, Leonte L, Garcia-Montolio M, Babloo Singh L, Findlay A, Deodhar M, Foot J, Jarolimek W, Timpson P, Erler JT#, Cox TR#
doi: 10.18632/oncotarget.15257
#Corresponding Authors
PubMed | HTML

28. Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC
PLoS ONE (2017)
doi: 10.1371/journal.pone.0169664
PubMed | HTML

27.  Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro

Cox TR# and Madsen CD#
Bio-protocol (2017)
doi: 10.21769/BioProtoc.2101
#Corresponding Authors

26. Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC
Scientific Reports (2017)
doi: 10.1038/s41598-017-00144-5
PubMed | HTML


25. The Role of Lysyl Oxidase, the Extracellular Matrix and the Pre-Metastatic Niche in Bone Metastasis

Gartland A, Erler JT and Cox TR
Journal of Bone Oncology (2016)
doi: 10.1016/j.jbo.2016.04.001
PubMed | HTML

24. Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Cox TR# and Erler JT#
Trends In Cancer (2016)
doi: 10.1016/j.trecan.2016.05.004
#Corresponding Authors

23. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients

Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF
Oncotarget (2016)
doi: 10.18632/oncotarget.9623

PubMed | HTML (Open Access)

22. Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis

Cox TR#, Gartland A, Erler JT
Cancer Research (2016)
doi: 10.1158/0008-5472.CAN-15-2306

#Corresponding Author
PubMed | HTML | PDF


21. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism

Cox TR#*, Schoof EM*, Gartland A, Erler JT, Linding R#
Data In Brief (2015)
doi: 10.1016/j.dib.2015.09.039

*First authors contributed equally
#Corresponding Authors
PubMed | HTML | PDF (Open Access)

20. Kinome-wide Decoding of Network Attacking Mutations Rewiring Cancer

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R
Cell (2015)
doi: 10.1016/j.cell.2015.08.056
PubMed | HTML | PDF (Open Access)

19. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.
EMBO Reports (2015)
doi: 10.15252/embr.201540107

PubMed | HTML | PDF (Open Access)

18. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird, D, Ab Latif N, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT.
Nature (2015)
doi: 10.1038/nature14492

PubMed | HTML | PDF (read-only) | HTML (Open Access on PMC)

17. AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

Rodriguez‐Teja M, Gronau JH, Breit C,  Zhang Y, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J
The Journal of Pathology (2015)
doi: 10.1002/path.4485
PubMed | HTML | PDF


16. Molecular pathways: connecting fibrosis and solid tumor metastasis

Cox TR# and Erler JT#
Clinical Cancer Research (2014)
doi: 10.1158/1078-0432.CCR-13-1059
#Corresponding Authors
PubMed | HTML | PDF

15. Lysyl oxidase in colorectal cancer

Cox TR and Erler JT
American Journal of Physiology – Gastrointestinal and Liver Physiology (2014)
PubMed | HTML | PDF


14. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling

Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT
Breast Cancer Research (2013)
doi: 10.1186/bcr3461
PubMed | HTML | PDF

13. The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis

Cox TR and Erler JT
Journal of Carcinogenesis & Mutagenesis (2013)
doi: 10.4172/2157-2518.S13-001

12. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis

Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT
Cancer Research (2013)
PubMed | HTML | PDF

11. Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis

Baker AM, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, Reynolds AR, Cox TR, Erler JT
Cancer Research (2013)
PubMed | HTML | PDF


10. Network biology and the 3-Dimensional tumor micro-environment: personalizing medicine for the future

Cox TR and Erler JT
Tumor Microenvironment and Therapy (2012)
doi: 10.2478/tumor-2012-0002

9. The rationale for targeting the LOX family in cancer

Barker HE*, Cox TR* and Erler JT
Nature Reviews Cancer (2012)
doi: 10.1038/nrc3319
*First authors contributed equally to this work
PubMed | HTML | PDF

8. The pre-metastatic niche: is metastasis random?

Cox TR, Gartland A and  Erler JT
BoneKEy Reports (2012)
doi: 10.1038/bonekey.2012.80
PubMed | HTML | PDF

7. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

Baker AM, Lang G, Bird D, Cox TR*, Erler JT*
Oncogene (2012)
doi: 10.1038/onc.2012.202
*Senior authors contributed equally
PubMed | HTML | PDF


6. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Cox TR and Erler JT
Disease Models and Mechanisms (2011)

PubMed | HTML | PDF

5. The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT
Journal of the National Cancer Institute (2011)
doi: 10.1093/jnci/djq569
PubMed | HTML | PDF

4. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution

Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT
Cancer Research (2011)
PubMed | HTML | PDF


3. Tissue section AFM: In situ ultrastructural imaging of native biomolecules

Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ
Matrix Biology (2010)
doi: 10.1016/j.matbio.2010.01.008
PubMed | HTML | PDF


2. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

Erler JT*, Bennewith KL*, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ
Cancer Cell (2009)
doi: 10.1016/j.ccr.2008.11.012
*These authors contributed equally to this work
PubMed | HTML | PDF


1. Lamin A/C is a risk biomarker in colorectal cancer

Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A, Hutchison CJ
PLOSOne (2008)
doi: 10.1371/journal.pone.0002988
PubMed | HTML | PDF


Methods for determining a prognosis of colorectal cancer. 

University of Durham (2007)
Inventors: TR Cox, A De Bruin, C Hutchison, S Przyborski, M Van Engeland, R Wilson

WO2007148095 A8

Invited Editorials

3. Transient targeting of the pancreatic cancer stroma as a ‘fine-tuned’ anti-tumor and anti-metastatic therapy

Vennin C, Cox TR, Pajic M, Timpson P
Oncotarget (2017)
doi: 10.18632/oncotarget.21468

2. Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis

Bankaitis K, Borriello L, Cox TR, Lynch C, Zijlstra A, Fingleton B, Gužvić M, Anderson R, Neman J
Clinical and Experimental Metastasis (2017)
doi: 10.1007/s10585-017-9842-1
PubMed | HTML

1. Fibrosis, cancer and the premetastatic niche

Cox TR# and Erler JT#
Breast Cancer Management (2014)
doi: 10.2217/bmt.14.36
#Corresponding Authors

Book Chapters

2. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments

El Rayes T, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment
Akslen, LA., Watnick, RS. (Eds.)
Springer International Publishing
ISBN 978-3-319-39147-2

1. Remodelling of the Extracellular Matrix: Implications for Cancer

Cox TR and Erler JT
In Cell and Molecular Biology of Breast Cancer
Schatten, H. (Ed.)
Humana Press, Springer (2013)
ISBN 978-1-62703-633-7
doi: 10.1007/978-1-62703-634-4


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