Publications

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Last update: 6th Nov 2017

Journal Articles (Peer-Reviewed)

2017

36. Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

Cox TR#, Erler JT and Rumney RMH#
Calcified Tissue International (2017)
doi: 10.1007/s00223-017-0352-6
PubMed | HTML
#Corresponding Authors

35. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

Chou A, Froio D, Nagrial AN, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ, Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M
Gut (2017)
doi: 10.1136/gutjnl-2017-315144
PubMed | HTML

34. Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments

Koplev S, Longden J,  Ferkinghoff-Borg J, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R
Cell Reports (2017)
doi: 10.1016/j.celrep.2017.08.095
PubMed | HTML

33. ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

Mayorca-Guiliani AE*, Madsen CD*, Cox TR*, Horton ER, Venning FA, Erler JT
Nature Medicine (2017) June 12
doi: 10.1038/nm.4352
PubMed | HTML | PDF
* First authors contributed equally

32. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec A, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Australian Pancreatic Cancer Genome Initiative (APGI), Evans TRJ, Anderson KI, Gray ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.
Science Translational Medicine (2017) Vol. 9, Issue 384, eaai8504
doi: 10.1126/scitranslmed.aai8504
PubMed | HTML

31. Relative Stiffness Measurements of Tumour Tissues by Shear Rheology

Madsen CD# and Cox TR#
Bio-protocol (2017) 7(9): e2265
doi: 10.21769/BioProtoc.2265
HTML
#Corresponding Author

30. Pre-metastatic niches: organ-specific  homes for metastases

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissel MJ, Cox TR, Giaccia A, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.
Nature Reviews Cancer (2017)
doi: 10.1038/nrc.2017.6
PubMed | HTML

29. Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

Chang J, Lucas M, Leonte L, Garcia-Montolio M, Babloo Singh L, Findlay A, Deodhar M, Foot J, Jarolimek W, Timpson P, Erler JT#, Cox TR#
Oncotarget 5
(2017)
doi: 10.18632/oncotarget.15257
#Corresponding Author
PubMed | HTML

28. Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC
PLoS ONE (2017) Jan 20; 12(1) e0169664
doi: 10.1371/journal.pone.0169664
PubMed | HTML

27.  Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro

Cox TR# and Madsen CD#
Bio-protocol (2017) 7(1): e2101
doi: 10.21769/BioProtoc.2101
#Corresponding Author
HTML

26. Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC
Scientific Reports (2017) 7(1):165
doi: 10.1038/s41598-017-00144-5
PubMed | HTML

2016

25. The Role of Lysyl Oxidase, the Extracellular Matrix and the Pre-Metastatic Niche in Bone Metastasis

Gartland A, Erler JT and Cox TR
Journal of Bone Oncology (2016)
doi: 10.1016/j.jbo.2016.04.001
PubMed | HTML

24. Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Cox TR# and Erler JT#
Trends In Cancer (2016)
doi: 10.1016/j.trecan.2016.05.004
#Corresponding Author
HTML

23. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients

Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF
Oncotarget (2016)
doi: 10.18632/oncotarget.9623

PubMed | HTML (Open Access)

22. Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis

Cox TR#, Gartland A, Erler JT
Cancer Research 76(2):188-92 (2016)
doi: 10.1158/0008-5472.CAN-15-2306

#Corresponding Author
PubMed | HTML | PDF

2015

21. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism

Cox TR#*, Schoof EM*, Gartland A, Erler JT, Linding R#
Data In Brief (5) 621-625 (2015)
doi: 10.1016/j.dib.2015.09.039

*First authors contributed equally
#Corresponding Authors
PubMed | HTML | PDF (Open Access)

20. Kinome-wide Decoding of Network Attacking Mutations Rewiring Cancer

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R
Cell 163, 1–16 (2015)
doi: 10.1016/j.cell.2015.08.056
PubMed | HTML | PDF (Open Access)

19. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.
EMBO Reports Aug 31 (2015) pii: e201540107
doi: 10.15252/embr.201540107

PubMed | HTML | PDF (Open Access)

18. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird, D, Ab Latif N, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT.
Nature 522, 106–110 (2015)
doi: 10.1038/nature14492

PubMed | HTML | PDF (read-only) | HTML (Open Access on PMC)

17. AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

Rodriguez‐Teja M, Gronau JH, Breit C,  Zhang Y, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J
The Journal of Pathology Mar;235(4):581-92 (2015)
doi: 10.1002/path.4485
PubMed | HTML | PDF

2014

16. Molecular pathways: connecting fibrosis and solid tumor metastasis

Cox TR# and Erler JT#
Clinical Cancer Research 20 (14), 3637-3643 (2014)
doi: 10.1158/1078-0432.CCR-13-1059
#Corresponding Authors
PubMed | HTML | PDF

15. Lysyl oxidase in colorectal cancer

Cox TR and Erler JT
American Journal of Physiology – Gastrointestinal and Liver Physiology 305 (10) 659-666 (2014)
doi:
PubMed | HTML | PDF

2013

14. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling

Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT
Breast Cancer Research 15 (4), R67 (2013)
doi: 10.1186/bcr3461
PubMed | HTML | PDF

13. The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis

Cox TR and Erler JT
Journal of Carcinogenesis & Mutagenesis Apr 30, S13:001 (2013)
doi: 10.4172/2157-2518.S13-001
HTML | PDF

12. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis

Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT
Cancer Research Mar 15;73(6):1721-32 (2013)
doi:
PubMed | HTML | PDF

11. Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis

Baker AM, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, Reynolds AR, Cox TR, Erler JT
Cancer Research Jan 15;73(2):583-94 (2013)
doi:
PubMed | HTML | PDF

2012

10. Network biology and the 3-Dimensional tumor micro-environment: personalizing medicine for the future

Cox TR and Erler JT
Tumor Microenvironment and Therapy (1), 14-18 (2012)
doi: 10.2478/tumor-2012-0002
HTML | PDF

9. The rationale for targeting the LOX family in cancer

Barker HE*, Cox TR* and Erler JT
Nature Reviews Cancer  Jul 19;12(8):540-52 (2012)
doi: 10.1038/nrc3319
*First authors contributed equally to this work
PubMed | HTML | PDF

8. The pre-metastatic niche: is metastasis random?

Cox TR, Gartland A and  Erler JT
BoneKEy Reports 1;80 (2012)
doi: 10.1038/bonekey.2012.80
PubMed | HTML | PDF

7. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

Baker AM, Lang G, Bird D, Cox TR*, Erler JT*
Oncogene Apr 4;32(14):1863-8 (2012)
doi: 10.1038/onc.2012.202
*Senior authors contributed equally
PubMed | HTML | PDF

2011

6. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Cox TR and Erler JT
Disease Models and Mechanisms Mar;4(2):165-78 (2011)

PubMed | HTML | PDF

5. The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT
Journal of the National Cancer Institute Mar 2;103(5):407-24 (2011)
doi: 10.1093/jnci/djq569
PubMed | HTML | PDF

4. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution

Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT
Cancer Research Mar 1;71(5):1561-72 (2011)
doi:
PubMed | HTML | PDF

2010

3. Tissue section AFM: In situ ultrastructural imaging of native biomolecules

Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ
Matrix Biology May;29(4):254-60 (2010)
doi: 10.1016/j.matbio.2010.01.008
PubMed | HTML | PDF

2009

2. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

Erler JT*, Bennewith KL*, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ
Cancer Cell Jan 6;15(1):35-44 (2009)
doi: 10.1016/j.ccr.2008.11.012
*These authors contributed equally to this work
PubMed | HTML | PDF

2008

1. Lamin A/C is a risk biomarker in colorectal cancer

Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A, Hutchison CJ
PLOSOne Aug 20;3(8):e2988 (2008)
doi: 10.1371/journal.pone.0002988
PubMed | HTML | PDF


Patents

Methods for determining a prognosis of colorectal cancer. 

University of Durham (2007)
Inventors: TR Cox, A De Bruin, C Hutchison, S Przyborski, M Van Engeland, R Wilson

WO2007148095 A8


Invited Editorials

3. Transient targeting of the pancreatic cancer stroma as a ‘fine-tuned’ anti-tumor and anti-metastatic therapy

Vennin C, Cox TR, Pajic M, Timpson P
Oncotarget (2017)
doi: 10.18632/oncotarget.21468
HTML

2. Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis

Bankaitis K, Borriello L, Cox TR, Lynch C, Zijlstra A, Fingleton B, Gužvić M, Anderson R, Neman J
Clinical and Experimental Metastasis (2017)
doi: 10.1007/s10585-017-9842-1
PubMed | HTML

1. Fibrosis, cancer and the premetastatic niche

Cox TR# and Erler JT#
Breast Cancer Management 3 (6), 453-455 (2014)
doi: 10.2217/bmt.14.36
#Corresponding Authors
HTML | PDF


Book Chapters

2. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments

El Rayes T, Gao D, Altorki NK, Cox TR, Erler JT and Mittal V
In Biomarkers of the Tumor Microenvironment
Akslen, LA., Watnick, RS. (Eds.)
Springer International Publishing
ISBN 978-3-319-39147-2
HTML

1. Remodelling of the Extracellular Matrix: Implications for Cancer

Cox TR and Erler JT
In Cell and Molecular Biology of Breast Cancer
Schatten, H. (Ed.)
Humana Press, Springer (2013)
ISBN 978-1-62703-633-7
doi: 10.1007/978-1-62703-634-4
HTML


Metrics

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