Targetting the Extracellular Matrix in Cancer Metastasis
The Matrix and Metastasis Lab is based at the Garvan Institute of Medical Research Kinghorn Cancer Centre in Sydney, Australia.
Our work is focused on tackling the knowledge gap in, and re-defining our understanding of the extracellular matrix (ECM) in diseases such as cancer. The lab strives to identify new matrix targets and matrix targeting approaches, as well as develop ways to maximise the effectiveness of pre-clinical cancer models for personalising new and/or current anti-cancer agents.
Our labs research vision integrates matrix biology with precision oncology to achieve the following goals
(1) Expand our repertoire of anti-cancer therapeutic targets to include matrix molecules and their effectors, critical component of all solid tumours, and drive forward our already established pipeline of anti-ECM drugs.
(2) Continue to develop and utilise powerful, state-of-the-art, physiologically relevant in vitro and in vivo 3D models that include native ECM to assay and streamline the evaluation of novel and existing therapies.
(3) Reshape the way we view the matrix, as an active contributor to cancer, not just a passive bystander, and leverage this to better stratify cancer patients for personalised stromal targeting in solid tumours.
Thomas R. Cox
Post Doctoral Research Fellow
Associate Lecturer (Conjoint) – UNSW Sydney
Matrix & Metastasis Lab Alumni
Gretel Major [2019-2020] – Research Assistant
Joanna Skhinas [2017-2020] – Research Assistant
Yordanos Setargew  – Honours Student (UNSW) – Graduated 1st Class Honours
Shivanjali Ratnaseelan  – Honours Student (UNSW) – Graduated 1st Class Honours
Elvan Kaya  – Visiting M.Sc. Student (University of Groningen, The Netherlands)
Tessa Boyles [2018-19] – Visiting Scientist (Dept. of Oncology, Herlev Hospital, Denmark)
See here for a full publication list
Work in the Matrix and Metastasis Lab is supported by the following funders: