Publication: Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

Thomas R. Cox, Apr 2017

ROCK-ing pancreatic cancer to the core

Our new paper on short-term pulsed treatment, or ‘priming’ as a treatment strategy to boost chemotherapy has just been published in Science Translational Medicine.

F1.medium.gif

STM Front Cover Vol 9 Issue 384 (Image: Timpson Laboratory, Garvan Institute)

 

The research, spearheaded by Dr. Paul Timpson and Dr. Marina Pajic here at the Garvan Institute of Medical Research in Sydney, has uncovered a promising new approach to treating pancreatic cancer. By targeting the tissue surrounding the tumour to make it ‘softer’, it leads to tumours being more responsive to chemotherapy.

Continue reading

Publication: Pre-metastatic niches: organ-specific homes for metastases

Thomas R. Cox, Mar 2017

Pre-metastatic niches: organ-specific homes for metastases

Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.

nrc.2017.6-f1.jpeg

What is the pre-metastatic niche (PMN)?

Continue reading

M&M welcomes Joanna Skhinas

Thomas R. Cox, Jan 2017

We are delighted to welcome our newest member, Joanna Skhinas, to the Matrix and Metastasis lab here at the Kinghorn Cancer Centre and Garvan Institute.

Matrix & Metastasis - Joanna SkhinasJoanna joins us as a research assistant having recently completed her Honours degree at the University of New South Wales. Joanna will work on our recently awarded NHMRC grant to understand more about how the stiffness of the extracellular matrix affects cancer progression and response to therapy.

Through joining our team, Joanna can pursue her “interest in cancer biology, in particular the interactions between cancer cells and the surrounding extracellular matrix, and the ECMs role in metastasis”

Publication: Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro

Thomas R. Cox, Jan 2017

Our new protocol on in vitro shear rheology of cell-embedded hydrogels has just been published in bio-protocol

Cox & Madsen - Bioprotocol

Bio-protocol (ISSN: 2331-8325) is a peer-viewed e-journal established in 2011 by a group of Stanford researchers. Their mission is to make life science research more efficient and reproducible by curating and hosting high quality, open access, life science protocols.

Continue reading

Funding: NHMRC New Investigator Grant to Thomas Cox

NHMRC Logo 1Thomas R. Cox, Dec 2017

We’re delighted to announce the we have been awarded a New Investigator Project Grant from the National Health and Medical Research Council (NHMRC).

The grant will support a project investigating how  targeting tumour tissue stiffness can increase the efficacy of currently approved therapies in breast and colon cancer. Continue reading

RA position available to start early 2017

Thomas R. Cox, Dec 2016

Matrix and Metastasis Lab Hiring

We are seeking a full-time dedicated research assistant to work in the Cancer Division Matrix & Metastasis Group headed by Dr. Thomas Cox.  The group combines the use of 3D models of cancer with novel state-of-the-art imaging approaches to reveal how the extracellular matrix drives cancer progression and metastasis. Our mission is to establish targeting of the extracellular matrix as a viable therapeutic approach in the treatment of solid cancers. Continue reading

Winner of the 2016 Herbert Tabor Young Investigator Award

Thomas R. Cox, Nov 2016

Herbert Tabor Young Investigator Award

It is an absolute honour to announce that I was awarded the Journal of Biological Chemistry (JBC) Herbert Tabor Young Investigator Award at the 2016 Matrix Biology Society of Australia and New Zealand (MBSANZ) conference.

The JBC Herbert Tabor Young Investigator Awards are meant to honour Dr. Tabor’s invaluable contributions to the journal and to science as a whole. The awards recognise the innovators and achievers in new generations of researchers who exemplify his values of creativity and scientific excellence. Continue reading

Invited speaker at 8th Garvan Signalling Symposium 2016

Thomas R. Cox, Oct 2016

I’m delighted to have been invited to speak at the upcoming 8th Garvan Signalling Symposium being held at the Garvan Institute of Medical Research in Sydney, Australia from 31st October – 1st November.

This is a short two day international symposium focusing on many different aspects of signalling across a wide range of tissues and organisms in both health and disease.

banner.png

Continue reading