Thomas R. Cox, Jan 2019
The extracellular matrix as a key regulator of intracellular signalling networks
Our latest review in collaboration with Dr. David Croucher and Dr. Dirk Fey on ‘The extracellular matrix as a key regulator of intracellular signalling networks‘ has just been published as part of a special series on ‘Translating the Matrix’ in the British Journal of Pharmacology.
Computational model of the interplay between the ECM and drug activated MAPK‐JNK signalling network.
At their simplest, cells follow a set of rules governed by their genetic code. These rules, which are executed by the protein‐based signalling networks that the genes encode, control the assimilation of information and decision‐making processes that shape a cell’s response to their surroundings.
Thomas R. Cox, Sep 2018
Recent advances in understanding the complexities of metastasis
We are excited to announce that our recent F1000 Faculty Invited Review on “Recent advances in understanding the complexities of metastasis” has just been published in F1000Research.
Thomas R. Cox, Apr 2018
Charting the unexplored extracellular matrix in cancer
Our new review on the recent advances in mapping the extracellular matrix in cancer has just been published in the International Journal of Experimental Pathology.
Composed of hundreds of different building blocks, the extracellular matrix (ECM) makes up the complex, highly cross‐linked, three‐dimensional (3D) network of macromolecules (proteins, glycoproteins and its subgroup of proteoglycans, polysaccharides (glycosaminoglycans), elastins and carbohydrates) that surround cells. It is essential to correct organisation and function of all tissues and organs, yet we know remarkably little about the assembly and organisation of these supramolecular structures of the ECM. In this review we discuss some of the recent advances and technologies that are helping us delve deeper into the matrix and further our understanding of the impact that dysregulated ECM has in diseases such as cancer.
Extracellular matrix building blocks
Thomas R. Cox, Jan 2018
Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Our new review on the how hypoxia is important in cancer-associated bone disease has just been published in Calcified Tissue International.
What is Hypoxia and why is it important in cancer?
Thomas R. Cox, Mar 2017
Pre-metastatic niches: organ-specific homes for metastases
Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.
What is the pre-metastatic niche (PMN)?
Thomas R. Cox, Oct 2016
Our new article as part of a special issue of the Journal of Bone Oncology focusing on The role of the microenvironment in bone metastasis is now out:
Thomas R. Cox, Jun 2016
Fibrosis and Cancer: Partners in Crime or Opposing Forces?
Our recent forum discussing the importance of cancer associated fibrosis in pancreatic cancer has just been published in Trends in Cancer
Targeting the Extracellular Matrix (ECM) in Pancreatic Ductal Adenocarcinoma (PDAC).
What is cancer associated fibrosis?
Thomas R. Cox, Jan 2016
Over the last 2 decades there has been a rapidly increasing number of research papers published (many from our own lab) investigating the function and role of a secreted enzyme called Lysyl Oxidase (LOX). Each paper has added successive small pieces to the complex puzzle of what exactly LOX does in both normal development and human disease, none less so than cancer.
The last decade has seen an explosion in the number of papers reporting on Lysyl Oxidase (LOX)
Thomas R. Cox, Oct 2014
Linking breast cancer progression and fibrosis through ECM remodelling
My recent editorial piece on ‘Fibrosis, cancer and the pre-metastatic niche’ has recently been published in Breast Cancer Management.
Image from Breast Cancer Management
In this short piece we discuss the interplay between cancer and fibrosis and look at the parallels between the two pathologies. Continue reading
Thomas R. Cox, Sep 2014
My recent review has just been published in the American Journal of Physiology; Gastrointestinal and Liver Physiology. Titled ‘Lysyl oxidase in colorectal cancer’, we discuss the current body of literature on the role of the extracellular matrix remodelling enzyme Lysyl Oxidase in colorectal cancer initiation and progression.
Image: The multiple roles of LOX in regulating signaling networks in colorectal cancer, both directly and indirectly.