Thomas R. Cox, Mar 2017
Pre-metastatic niches: organ-specific homes for metastases
Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.
What is the pre-metastatic niche (PMN)?
Thomas R. Cox, Oct 2016
Our new article as part of a special issue of the Journal of Bone Oncology focusing on The role of the microenvironment in bone metastasis is now out:
Thomas R. Cox, Jun 2016
Fibrosis and Cancer: Partners in Crime or Opposing Forces?
Our recent forum discussing the importance of cancer associated fibrosis in pancreatic cancer has just been published in Trends in Cancer
Targeting the Extracellular Matrix (ECM) in Pancreatic Ductal Adenocarcinoma (PDAC).
What is cancer associated fibrosis?
Thomas R. Cox, Jan 2016
Over the last 2 decades there has been a rapidly increasing number of research papers published (many from our own lab) investigating the function and role of a secreted enzyme called Lysyl Oxidase (LOX). Each paper has added successive small pieces to the complex puzzle of what exactly LOX does in both normal development and human disease, none less so than cancer.
The last decade has seen an explosion in the number of papers reporting on Lysyl Oxidase (LOX)
Thomas R. Cox, Oct 2014
Linking breast cancer progression and fibrosis through ECM remodelling
My recent editorial piece on ‘Fibrosis, cancer and the pre-metastatic niche’ has recently been published in Breast Cancer Management.
Image from Breast Cancer Management
In this short piece we discuss the interplay between cancer and fibrosis and look at the parallels between the two pathologies. Continue reading
Thomas R. Cox, Sep 2014
My recent review has just been published in the American Journal of Physiology; Gastrointestinal and Liver Physiology. Titled ‘Lysyl oxidase in colorectal cancer’, we discuss the current body of literature on the role of the extracellular matrix remodelling enzyme Lysyl Oxidase in colorectal cancer initiation and progression.
Image: The multiple roles of LOX in regulating signaling networks in colorectal cancer, both directly and indirectly.
Thomas R. Cox, Jul 2014
Image: Clinical Cancer Research; Molecular Pathways – Connecting Fibrosis and Solid Tumour Metastasis
My Molecular Pathways feature has just been accepted for publication in Clinical Cancer Research. Titled Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis it discusses the current and recent work in the field looking at the overlap between mechanisms underlying two pathological diseases; cancer and tissue fibrosis. Continue reading
Thomas R. Cox, Apr 2013
My recent review on The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis has just been published in The journal of Carcinogenesis & Mutagenesis.
Image: Structure homology of the LOX Family Members
Thomas R. Cox, Dec 2012
My recent mini-review has just been published in Tumor Microenvironment and Therapy. The review is titled “Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future” and discusses the importance of applying network biology approaches to physiologically relevant 3-Dimensional models of cancer and cancer metastasis. Continue reading
Thomas R. Cox, Aug 2012
My review on the potential of therapeutic targeting of the Lysyl Oxidase (LOX) family in cancer has just been published in this months edition of Nature Reviews Cancer.
Our review discusses the recent breakthroughs which have been made in understanding the role of Lysyl Oxidase and its related family members in cancer initiation, progression and metastasis, and the progress which is being made into targeting these molecules in cancer treatment
Image: Nature Reviews Cancer; The multiple intracellular and extracellular roles of LOX and LOX family members in cancer cell signalling, transcription and translation.