Category Archives: Reviews

Publication: Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease


Thomas R. Cox, Nov 2017

Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

Our new review on the how hypoxia is important in cancer-associated bone disease has just been published in Calcified Tissue International.


What is Hypoxia and why is it important in cancer?

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Publication: Pre-metastatic niches: organ-specific homes for metastases

Thomas R. Cox, Mar 2017

Pre-metastatic niches: organ-specific homes for metastases

Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.


What is the pre-metastatic niche (PMN)?

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Publication: Tissue Fibrosis and Pancreatic Cancer

Thomas R. Cox, Jun 2016

Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Our recent forum discussing the importance of cancer associated fibrosis in pancreatic cancer has just been published in Trends in Cancer


Targeting the Extracellular Matrix (ECM) in Pancreatic Ductal Adenocarcinoma (PDAC).

What is cancer associated fibrosis?

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Publication: Targeting LOX in Cancer

Thomas R. Cox, Jan 2016

Over the last 2 decades there has been a rapidly increasing number of research papers published (many from our own lab) investigating the function and role of a secreted enzyme called Lysyl Oxidase (LOX). Each paper has added successive small pieces to the complex puzzle of what exactly LOX does in both normal development and human disease, none less so than cancer.

LOX publications by year

The last decade has seen an explosion in the number of papers reporting on Lysyl Oxidase (LOX)

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Publication: New Editorial published in Breast Cancer Management

Thomas R. Cox, Oct 2014

Linking breast cancer progression and fibrosis through ECM remodelling

My recent editorial piece on ‘Fibrosis, cancer and the pre-metastatic niche’ has recently been published in Breast Cancer Management.


Image from Breast Cancer Management

In this short piece we discuss the interplay between cancer and fibrosis and look at the parallels between the two pathologies. Continue reading

Publication: New Review published in Am. J. Physiol; Gastrointestinal & Liver Physiology

Thomas R. Cox, Sep 2014

My recent review has just been published in the American Journal of Physiology; Gastrointestinal and Liver Physiology. Titled ‘Lysyl oxidase in colorectal cancer’, we discuss the current body of literature on the role of the extracellular matrix remodelling enzyme Lysyl Oxidase in colorectal cancer initiation and progression.


Image: The multiple roles of LOX in regulating signaling networks in colorectal cancer, both directly and indirectly.

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Publication: New Molecular Pathways feature published in Clinical Cancer Research

Thomas R. Cox, Jul 2014


Image: Clinical Cancer Research; Molecular Pathways – Connecting Fibrosis and Solid Tumour Metastasis

My Molecular Pathways feature has just been accepted for publication in Clinical Cancer Research. Titled Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis it discusses the current and recent work in the field looking at the overlap between mechanisms underlying two pathological diseases; cancer and tissue fibrosis.  Continue reading

Publication: New Mini-Review published in Tumor Microenvironment and Therapy

Thomas R. Cox, Dec 2012


My recent mini-review has just been published in Tumor Microenvironment and Therapy. The review is titled “Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future” and discusses the importance of applying network biology approaches to physiologically relevant 3-Dimensional models of cancer and cancer metastasis. Continue reading