Thomas R. Cox, Sep 2015
Linding Lab publishes back-to-back papers in Cell explaining how genetic cancer mutations systematically attack the networks controlling human cells
Today Professor Rune Linding at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen (UCPH) along with collaborators at BRIC UCPH, Yale, University of Zurich (UZH), University of Rome and University of Tottori, have published back-to-back papers in Cell unravelling how disease mutations target and damage the protein signalling networks within human cells.
doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057
Thomas R. Cox, Sep 2015
I’m pleased to announce that our recent paper on Cancer-Associated-Fibroblasts (CAFs) in cancer has just been published in the Journal EMBO Reports titled “Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.“
Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
In this paper we show that chronic hypoxia (lack of oxygen) within primary tumours leads to a deactivation of cancer associated fibroblasts. Continue reading
Thomas R. Cox, May 2015
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
My research paper titled ‘The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase‘ which looked at how secreted factors from breast cancers can drive pre-metastatic niche formation in the bone to enhance tumour metastasis has just been published in Nature.
Image: Nature – Schematic of Lysyl Oxidase (LOX)-mediated effects on bone homeostasis during breast cancer spread
Thomas R. Cox, Dec 2014
Endo180 and ECM stiffness cooperate to drive progression in prostate cancer
Our recent collaborative article titled “AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival” has just been published in The Journal of Pathology.
“How a stiff microenvironment promotes prostate cancer progression”
Image: Confocal microscopy of cancer cell acini grown in native or stiff environments
As our body ages, our tissues get stiffer and it is thought that this stiffening is important in the progression of cancer. In this paper Continue reading
Thomas R. Cox, Oct 2014
Linking breast cancer progression and fibrosis through ECM remodelling
My recent editorial piece on ‘Fibrosis, cancer and the pre-metastatic niche’ has recently been published in Breast Cancer Management.
Image from Breast Cancer Management
In this short piece we discuss the interplay between cancer and fibrosis and look at the parallels between the two pathologies. Continue reading
Thomas R. Cox, Sep 2014
My recent review has just been published in the American Journal of Physiology; Gastrointestinal and Liver Physiology. Titled ‘Lysyl oxidase in colorectal cancer’, we discuss the current body of literature on the role of the extracellular matrix remodelling enzyme Lysyl Oxidase in colorectal cancer initiation and progression.
Image: The multiple roles of LOX in regulating signaling networks in colorectal cancer, both directly and indirectly.
Thomas R. Cox, Jul 2014
Image: Clinical Cancer Research; Molecular Pathways – Connecting Fibrosis and Solid Tumour Metastasis
My Molecular Pathways feature has just been accepted for publication in Clinical Cancer Research. Titled Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis it discusses the current and recent work in the field looking at the overlap between mechanisms underlying two pathological diseases; cancer and tissue fibrosis. Continue reading
Thomas R. Cox, Aug 2013
Our recent article on the role of Lysyl Oxidase-like 2 (LOXL2) in breast cancer invasion and metastasis has just been published in Breast Cancer Research.
Image: Overexpressing the LOXL-2 protein (10A L2) fails to affect MCF10A breast cancer cells compared to control (10A cont)
In this paper we show that LOXL2 expression in normal epithelial cells of the breast can induce abnormal changes that resemble oncogenic transformation and cancer progression. We provide evidence to support that these effects are driven by LOXL2-mediated activation of ErbB2 Continue reading
Thomas R. Cox, Apr 2013
My recent review on The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis has just been published in The journal of Carcinogenesis & Mutagenesis.
Image: Structure homology of the LOX Family Members
Thomas R. Cox, Jan 2013
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
My recent research article on LOX-mediated collagen crosslinking and its role in fibrosis-enhanced metastasis has just been published in the journal Cancer Research.
Image: Breast cancer cells (green) which have spread to and are growing in the lung
Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance tumor progression and metastasis, the underlying molecular mechanisms are still unclear. Continue reading
Thomas R. Cox, Jan 2013
Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
Our recent work on the role of Lysyl Oxidase in stimulating tumour angiogenesis in colorectal cancer has just been published in Cancer Research.
Image: Immunohistochemistry for LOX expression (shown in brown) in a patient colorectal cancer sample
In this paper we show that the cancer secreted enzyme Lysyl Oxidase (LOX) plays a critical role in stimulating angiogenesis in the growth of colorectal cancers. Continue reading
Thomas R. Cox, Dec 2012
My recent mini-review has just been published in Tumor Microenvironment and Therapy. The review is titled “Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future” and discusses the importance of applying network biology approaches to physiologically relevant 3-Dimensional models of cancer and cancer metastasis. Continue reading
Thomas R. Cox, Aug 2012
My review on the potential of therapeutic targeting of the Lysyl Oxidase (LOX) family in cancer has just been published in this months edition of Nature Reviews Cancer.
Our review discusses the recent breakthroughs which have been made in understanding the role of Lysyl Oxidase and its related family members in cancer initiation, progression and metastasis, and the progress which is being made into targeting these molecules in cancer treatment
Image: Nature Reviews Cancer; The multiple intracellular and extracellular roles of LOX and LOX family members in cancer cell signalling, transcription and translation.