Category Archives: Research Publications

Publication: Digital ‘Rosetta Stone’ able to decipher how genetic mutations rewire signalling in cancer cells

Thomas R. Cox, Sep 2015

Linding Lab publishes back-to-back papers in Cell explaining how genetic cancer mutations systematically attack the networks controlling human cells

Today Professor Rune Linding at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen (UCPH) along with collaborators at BRIC UCPH, Yale, University of Zurich (UZH), University of Rome and University of Tottori, have published back-to-back papers in Cell unravelling how disease mutations target and damage the protein signalling networks within human cells.

doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057

doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057

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Publication: Our new paper is out in EMBO Reports

Thomas R. Cox, Sep 2015

I’m pleased to announce that our recent paper on Cancer-Associated-Fibroblasts (CAFs) in cancer has just been published in the Journal EMBO Reports titled “Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

In this paper we show that chronic hypoxia (lack of oxygen) within primary tumours leads to a deactivation of cancer associated fibroblasts. Continue reading

Altmetric score nears 200 in the first 7 days after publication

Thomas R. Cox, Jun 2015

Soaring Altmetrics

Our recent paper “The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase published in Nature last week has soared to 175 in the first 7 days.

Altmetrics hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Altmetrics of our paper as of 18:00 CET 03/07/15 – 7 days post publication

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Publication: Nature – Hypoxic breast cancer secretomes enhance bone metastasis through LOX

Thomas R. Cox, May 2015

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

My research paper titled ‘The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase‘ which looked at how secreted factors from breast cancers can drive pre-metastatic niche formation in the bone to enhance tumour metastasis has just been published in Nature.

Breast Cancer Lysyl Oxidase LOX Bone Enzyme

Image: Nature – Schematic of Lysyl Oxidase (LOX)-mediated effects on bone homeostasis during breast cancer spread

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Publication: Journal of Pathology – AGE-modified basement membrane cooperates with Endo180 in prostate cancer

Thomas R. Cox, Dec 2014

Endo180 and ECM stiffness cooperate to drive progression in prostate cancer

Our recent collaborative article titled “AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival” has just been published in The Journal of Pathology.

“How a stiff microenvironment promotes prostate cancer progression”

Prostate cancer acini affected by ECM stiffness

Image: Confocal microscopy of cancer cell acini grown in native or stiff environments

As our body ages, our tissues get stiffer and it is thought that this stiffening is important in the progression of cancer. In this paper Continue reading

Publication: New Editorial published in Breast Cancer Management

Thomas R. Cox, Oct 2014

Linking breast cancer progression and fibrosis through ECM remodelling

My recent editorial piece on ‘Fibrosis, cancer and the pre-metastatic niche’ has recently been published in Breast Cancer Management.

BCM_editorial

Image from Breast Cancer Management

In this short piece we discuss the interplay between cancer and fibrosis and look at the parallels between the two pathologies. Continue reading

Publication: New Review published in Am. J. Physiol; Gastrointestinal & Liver Physiology

Thomas R. Cox, Sep 2014

My recent review has just been published in the American Journal of Physiology; Gastrointestinal and Liver Physiology. Titled ‘Lysyl oxidase in colorectal cancer’, we discuss the current body of literature on the role of the extracellular matrix remodelling enzyme Lysyl Oxidase in colorectal cancer initiation and progression.

AJP13_Fig

Image: The multiple roles of LOX in regulating signaling networks in colorectal cancer, both directly and indirectly.

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Publication: New Molecular Pathways feature published in Clinical Cancer Research

Thomas R. Cox, Jul 2014

CCR14_Fig

Image: Clinical Cancer Research; Molecular Pathways – Connecting Fibrosis and Solid Tumour Metastasis

My Molecular Pathways feature has just been accepted for publication in Clinical Cancer Research. Titled Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis it discusses the current and recent work in the field looking at the overlap between mechanisms underlying two pathological diseases; cancer and tissue fibrosis.  Continue reading

Publication: New Article published in Breast Cancer Research

Thomas R. Cox, Aug 2013

Our recent article on the role of Lysyl Oxidase-like 2 (LOXL2) in breast cancer invasion and metastasis has just been published in Breast Cancer Research.

BCR_MCF10A

Image: Overexpressing the LOXL-2 protein (10A L2) fails to affect MCF10A breast cancer cells compared to control (10A cont)

In this paper we show that LOXL2 expression in normal epithelial cells of the breast can induce abnormal changes that resemble oncogenic transformation and cancer progression. We provide evidence to support that these effects are driven by LOXL2-mediated activation of ErbB2 Continue reading

Publication: New Article on LOX in Fibrosis and Metastasis published in Cancer Research

Thomas R. Cox, Jan 2013

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

My recent research article on LOX-mediated collagen crosslinking and its role in fibrosis-enhanced metastasis has just been published in the journal Cancer Research.

CanRes_IF Image

Image: Breast cancer cells (green) which have spread to and are growing in the lung

Abstract

Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance tumor progression and metastasis, the underlying molecular mechanisms are still unclear. Continue reading

Publication: New Article on LOX and tumour angiogenesis published in Cancer Research

Thomas R. Cox, Jan 2013

Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis

Our recent work on the role of Lysyl Oxidase in stimulating tumour angiogenesis in colorectal cancer has just been published in Cancer Research.

Baker_CR_LOX

Image: Immunohistochemistry for LOX expression (shown in brown) in a patient colorectal cancer sample

In this paper we show that the cancer secreted enzyme Lysyl Oxidase (LOX) plays a critical role in stimulating angiogenesis in the growth of colorectal cancers. Continue reading

Publication: New Mini-Review published in Tumor Microenvironment and Therapy

Thomas R. Cox, Dec 2012

TMT_cloud

My recent mini-review has just been published in Tumor Microenvironment and Therapy. The review is titled “Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future” and discusses the importance of applying network biology approaches to physiologically relevant 3-Dimensional models of cancer and cancer metastasis. Continue reading

Publication: New Review published in Nature Reviews Cancer

Thomas R. Cox, Aug 2012

My review on the potential of therapeutic targeting of the Lysyl Oxidase (LOX) family in cancer has just been published in this months edition of Nature Reviews Cancer.

Our review discusses the recent breakthroughs which have been made in understanding the role of Lysyl Oxidase and its related family members in cancer initiation, progression and metastasis, and the progress which is being made into targeting these molecules in cancer treatment

Nature Reviews Cancer

Image: Nature Reviews Cancer; The multiple intracellular and extracellular roles of LOX and LOX family members in cancer cell signalling, transcription and translation.

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