Category Archives: Research Publications

Publication: Tissue Fibrosis and Pancreatic Cancer

Thomas R. Cox, Jun 2016

Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Our recent forum discussing the importance of cancer associated fibrosis in pancreatic cancer has just been published in Trends in Cancer

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Targeting the Extracellular Matrix (ECM) in Pancreatic Ductal Adenocarcinoma (PDAC).

What is cancer associated fibrosis?

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Publication: The importance of Lysyl Oxidase (LOX) in Rectal Cancer

Thomas R. Cox, May 2016

In collaboration with the department of oncology and department of clinical and experimental medicine at Linköping University in Sweden, we have just published a new paper looking at the importance of lysyl oxidase (LOX) in rectal cancer patients.

LOX+Rectal2016

Lysyl oxidase immunohistochemistry in rectal cancer samples

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Publication: Targeting LOX in Cancer

Thomas R. Cox, Jan 2016

Over the last 2 decades there has been a rapidly increasing number of research papers published (many from our own lab) investigating the function and role of a secreted enzyme called Lysyl Oxidase (LOX). Each paper has added successive small pieces to the complex puzzle of what exactly LOX does in both normal development and human disease, none less so than cancer.

LOX publications by year

The last decade has seen an explosion in the number of papers reporting on Lysyl Oxidase (LOX)

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Publication: Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism

Thomas R. Cox, Nov 2015

As part of our recent Nature paper (see previous post here) we sought to catalogue all of the different proteins secreted by breast cancer cells (the secretome) under conditions of hypoxia (low oxygen). Hypoxia is a common feature of most solid tumours and is very important in determining how cancer cells behave. Our hypothesis was that the breast cancer secretome changes under hypoxic conditions and that these changes were important in determining the how a patient’s tumour spreads around the body.

To create this catalogue, we performed Mass Spectrometry, a powerful analytical chemistry technique which allows us to both indentify and quantify proteins in a given sample. By creating a list of all the proteins present in the secretome of breast cancer cells, we were able to identify important proteins which may be responsible for determining how and where breast cancer spreads. In our paper we chose to focus specifically on one of these identified secreted proteins called Lysyl Oxidase (LOX).

Open Access – Open Data

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Publication: Digital ‘Rosetta Stone’ able to decipher how genetic mutations rewire signalling in cancer cells

Thomas R. Cox, Sep 2015

Linding Lab publishes back-to-back papers in Cell explaining how genetic cancer mutations systematically attack the networks controlling human cells

Today Professor Rune Linding at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen (UCPH) along with collaborators at BRIC UCPH, Yale, University of Zurich (UZH), University of Rome and University of Tottori, have published back-to-back papers in Cell unravelling how disease mutations target and damage the protein signalling networks within human cells.

doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057

doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057

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Publication: Our new paper is out in EMBO Reports

Thomas R. Cox, Sep 2015

I’m pleased to announce that our recent paper on Cancer-Associated-Fibroblasts (CAFs) in cancer has just been published in the Journal EMBO Reports titled “Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

In this paper we show that chronic hypoxia (lack of oxygen) within primary tumours leads to a deactivation of cancer associated fibroblasts. Continue reading

Altmetric score nears 200 in the first 7 days after publication

Thomas R. Cox, Jun 2015

Soaring Altmetrics

Our recent paper “The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase published in Nature last week has soared to 175 in the first 7 days.

Altmetrics hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Altmetrics of our paper as of 18:00 CET 03/07/15 – 7 days post publication

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Publication: Nature – Hypoxic breast cancer secretomes enhance bone metastasis through LOX

Thomas R. Cox, May 2015

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

My research paper titled ‘The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase‘ which looked at how secreted factors from breast cancers can drive pre-metastatic niche formation in the bone to enhance tumour metastasis has just been published in Nature.

Breast Cancer Lysyl Oxidase LOX Bone Enzyme

Image: Nature – Schematic of Lysyl Oxidase (LOX)-mediated effects on bone homeostasis during breast cancer spread

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Publication: Journal of Pathology – AGE-modified basement membrane cooperates with Endo180 in prostate cancer

Thomas R. Cox, Dec 2014

Endo180 and ECM stiffness cooperate to drive progression in prostate cancer

Our recent collaborative article titled “AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival” has just been published in The Journal of Pathology.

“How a stiff microenvironment promotes prostate cancer progression”

Prostate cancer acini affected by ECM stiffness

Image: Confocal microscopy of cancer cell acini grown in native or stiff environments

As our body ages, our tissues get stiffer and it is thought that this stiffening is important in the progression of cancer. In this paper Continue reading