Thomas R. Cox, Mar 2019
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
We have just published a new paper in Breast Cancer Research in collaboration with lead researcher Dr. David Croucher from the Garvan Institute, looking at how and why ERBB2 (HER2) positive breast cancer cells develop resistance to targeted therapies such as trastuzumab (Herceptin™).
Thomas R. Cox, Dec 2017
Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology
Our new paper on alternative collagen sources for 3D organotypic cultures for use as pre-clinical models is now out in Scientific Reports
Cellular interactions with the extracellular matrix (ECM) occur in a three-dimensional (3D) context and this essential aspect of the tumour microenvironment can lead to altered sensitivity to therapeutics and even act as a barrier to their delivery. This key feature is often overlooked in pre-clinical studies and is likely one of the central factors contributing to the high attrition rates of lead compounds within the pharmaceutical industry. This organotypic platform allows assessment of lead compounds in both the stromal compartment or in a 3D co-culture setting using large scale collagen preparations from alternative sources.
Thomas R. Cox, Nov 2017
Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Our new review on the how hypoxia is important in cancer-associated bone disease has just been published in Calcified Tissue International.
What is Hypoxia and why is it important in cancer?
Thomas R. Cox, July 2017
I was recently invited to chat with Norman Swan on ABC Radio National’s Health report about some of the recent work we have been doing on the Extracellular Matrix in cancer.
The extracellular matrix or the matrix is the web- or mesh-like structure that encases the cells in the tissues and organs of our body.
Image: Mayorca-Guiliani AE, Madsen CD, Cox TR et al. Nature Medicine (2017)
We recently developed a new technique which dissolves the cells from tumours to leave behind this matrix, allowing us to study it in unprecedented detail – and we discuss the potential of these research outcomes. Continue reading
Thomas R. Cox, Jun 2017
“We’re seeing things we’ve never seen before”: groundbreaking new technique sheds light on the ‘matrix’ surrounding our cells
Our most recent research has just been published in Nature Medicine.
In our paper we describe a new and intuitive new way to dissolve cells from tissues, leaving behind the extracellular matrix (ECM) or ‘matrix’.
The matrix is made up of 100’s of differing building blocks and surrounds the cells in our body. It is incredibly important in the progression and spread of cancer – but up until now it has been notoriously difficult to study in detail.
‘ISDoT’ mammary gland during lactation stained for the extracellular matrix (ECM) molecule Collagen IV
Thomas R. Cox, May 2017
Our new protocol on shear rheology of tumour tissues to measure tumour stiffness has just been published in bio-protocol
Thomas R. Cox, Apr 2017
ROCK-ing pancreatic cancer to the core
Our new paper on short-term pulsed treatment, or ‘priming’ as a treatment strategy to boost chemotherapy has just been published in Science Translational Medicine.
STM Front Cover Vol 9 Issue 384 (Image: Timpson Laboratory, Garvan Institute)
The research, spearheaded by Dr. Paul Timpson and Dr. Marina Pajic here at the Garvan Institute of Medical Research in Sydney, has uncovered a promising new approach to treating pancreatic cancer. By targeting the tissue surrounding the tumour to make it ‘softer’, it leads to tumours being more responsive to chemotherapy.
Thomas R. Cox, Mar 2017
Pre-metastatic niches: organ-specific homes for metastases
Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.
What is the pre-metastatic niche (PMN)?
Thomas R. Cox, Feb 2017
Our new paper on the pre-clinical testing of two novel potential anti-cancer drugs in breast cancer has just been published in Oncotarget.
Thomas R. Cox, Jan 2017
Our new protocol on in vitro shear rheology of cell-embedded hydrogels has just been published in bio-protocol
Bio-protocol (ISSN: 2331-8325) is a peer-viewed e-journal established in 2011 by a group of Stanford researchers. Their mission is to make life science research more efficient and reproducible by curating and hosting high quality, open access, life science protocols.