Category Archives: Prostate Cancer

Publication: Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment

Thomas R. Cox, May 2019

Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment

A new paper has just been published revealing the role of Lysyl Oxidase Like 2 (LOXL2) in the remodelling of the prostate cancer microenvironment. The work, carried out in collaboration with lead researchers from the Cancer Program, Biomedicine Discovery Institute at Monash University has just been published in Molecular and Cellular Proteomics.

Normal Prostate Fibroblast and Cancer Associated Fibroblast proteomics

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Publication: Journal of Pathology – AGE-modified basement membrane cooperates with Endo180 in prostate cancer

Thomas R. Cox, Dec 2014

Endo180 and ECM stiffness cooperate to drive progression in prostate cancer

Our recent collaborative article titled “AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival” has just been published in The¬†Journal of Pathology.

“How a stiff microenvironment promotes prostate cancer progression”

Prostate cancer acini affected by ECM stiffness

Image: Confocal microscopy of cancer cell acini grown in native or stiff environments

As our body ages, our tissues get stiffer and it is thought that this stiffening is important in the progression of cancer. In this paper Continue reading