Category Archives: Prostate Cancer

Publication: Journal of Pathology – AGE-modified basement membrane cooperates with Endo180 in prostate cancer

Thomas R. Cox, Dec 2014

Endo180 and ECM stiffness cooperate to drive progression in prostate cancer

Our recent collaborative article titled “AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival” has just been published in The¬†Journal of Pathology.

“How a stiff microenvironment promotes prostate cancer progression”

Prostate cancer acini affected by ECM stiffness

Image: Confocal microscopy of cancer cell acini grown in native or stiff environments

As our body ages, our tissues get stiffer and it is thought that this stiffening is important in the progression of cancer. In this paper Continue reading