Category Archives: Garvan

Funding: Susan G. Komen® Career Catalyst Research Grant

SGK logo 2017Thomas R. Cox, Sep 2017

We’re delighted to announce the we have been awarded a research grant from the Susan G. Komen Foundation, the world’s leading breast cancer organisation.

The grant will support a project investigating how stiffness in breast tissue can drive the aggressive behaviour of cancer cells, and how tissue stiffness impacts on the effectiveness of breast cancer treatments

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PostDoc position available to start late 2017

Thomas R. Cox, Aug 2017

Matrix and Metastasis Lab Hiring

We are seeking a full-time dedicated PostDoc to work in the Cancer Division Matrix & Metastasis Group headed by Dr. Thomas Cox.  The group combines the use of 3D models of cancer with novel state-of-the-art imaging approaches to reveal how the extracellular matrix drives cancer progression and metastasis. Our mission is to establish targeting of the extracellular matrix as a viable therapeutic approach in the treatment of solid cancers.

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Matrix: Dissolved – ABC Radio Network Health Report

ABC RN.pngThomas R. Cox, July 2017

I was recently invited to chat with Norman Swan on ABC Radio National’s Health report about some of the recent work we have been doing on the Extracellular Matrix in cancer.

The extracellular matrix or the matrix is the web- or mesh-like structure that encases the cells in the tissues and organs of our body.

ISDoT Mammary Fat Pad

Image: Mayorca-Guiliani AE, Madsen CD, Cox TR et al. Nature Medicine (2017)

We recently developed a new technique which dissolves the cells from tumours to leave behind this matrix, allowing us to study it in unprecedented detail – and we discuss the potential of these research outcomes. Continue reading

Publication: Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

Thomas R. Cox, Apr 2017

ROCK-ing pancreatic cancer to the core

Our new paper on short-term pulsed treatment, or ‘priming’ as a treatment strategy to boost chemotherapy has just been published in Science Translational Medicine.

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STM Front Cover Vol 9 Issue 384 (Image: Timpson Laboratory, Garvan Institute)

 

The research, spearheaded by Dr. Paul Timpson and Dr. Marina Pajic here at the Garvan Institute of Medical Research in Sydney, has uncovered a promising new approach to treating pancreatic cancer. By targeting the tissue surrounding the tumour to make it ‘softer’, it leads to tumours being more responsive to chemotherapy.

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M&M welcomes Joanna Skhinas

Thomas R. Cox, Jan 2017

We are delighted to welcome our newest member, Joanna Skhinas, to the Matrix and Metastasis lab here at the Kinghorn Cancer Centre and Garvan Institute.

Matrix & Metastasis - Joanna SkhinasJoanna joins us as a research assistant having recently completed her Honours degree at the University of New South Wales. Joanna will work on our recently awarded NHMRC grant to understand more about how the stiffness of the extracellular matrix affects cancer progression and response to therapy.

Through joining our team, Joanna can pursue her “interest in cancer biology, in particular the interactions between cancer cells and the surrounding extracellular matrix, and the ECMs role in metastasis”

Funding: NHMRC New Investigator Grant to Thomas Cox

NHMRC Logo 1Thomas R. Cox, Dec 2017

We’re delighted to announce the we have been awarded a New Investigator Project Grant from the National Health and Medical Research Council (NHMRC).

The grant will support a project investigating how  targeting tumour tissue stiffness can increase the efficacy of currently approved therapies in solid cancers. Continue reading

RA position available to start early 2017

Thomas R. Cox, Dec 2016

Matrix and Metastasis Lab Hiring

We are seeking a full-time dedicated research assistant to work in the Cancer Division Matrix & Metastasis Group headed by Dr. Thomas Cox.  The group combines the use of 3D models of cancer with novel state-of-the-art imaging approaches to reveal how the extracellular matrix drives cancer progression and metastasis. Our mission is to establish targeting of the extracellular matrix as a viable therapeutic approach in the treatment of solid cancers. Continue reading