Category Archives: Breast Cancer

Hvis kræft ikke spredte sig, var det ikke så farligt

Thomas R. Cox, Nov 2015

Kræfts evne til at sprede sig er en af de største udfordringer i bekæmpelsen af sygdommen. Har kræften spredt sig, bliver den nemlig meget sværere at få has på. Brystkræft, som årligt rammer næsten 4.900 danske kvinder, er blandt de kræftformer, som ofte spreder sig.

Nanna Bisbjerg fra Rask magasinet forsøger at forstå spredningen af kræft og har talt med Janine Erler og hendes team på Biotech Research and Innovation Centre (BRIC) på Københavns Universitet (KU) om fremtiden og hendes seneste forskning på området.

Den online version (kun på dansk) af artiklen kan findes i denne måneds Rask Magasinet her

Alternativt kan downloade en .pdf kopi af artiklen her

(English below)


27% af alle kræfttilfælde blandt kvinder er brystkræft, hvilket svarer til at 13 kvinder hver dag får diagnosen. Hvis brystkræft spreder sig, sker det typisk til lunger, lever og knogler. Screening betyder heldigvis, at de fleste tilfælde opdages tidligt. (27% of all cancers among women are breast cancer, this means that 13 women are diagnosed every day. If breast cancer spreads, it typically goes to the lungs, liver and bone. With screening, fortunately, most cases are detected early)

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Publication: Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism

Thomas R. Cox, Nov 2015

As part of our recent Nature paper (see previous post here) we sought to catalogue all of the different proteins secreted by breast cancer cells (the secretome) under conditions of hypoxia (low oxygen). Hypoxia is a common feature of most solid tumours and is very important in determining how cancer cells behave. Our hypothesis was that the breast cancer secretome changes under hypoxic conditions and that these changes were important in determining the how a patient’s tumour spreads around the body.

To create this catalogue, we performed Mass Spectrometry, a powerful analytical chemistry technique which allows us to both indentify and quantify proteins in a given sample. By creating a list of all the proteins present in the secretome of breast cancer cells, we were able to identify important proteins which may be responsible for determining how and where breast cancer spreads. In our paper we chose to focus specifically on one of these identified secreted proteins called Lysyl Oxidase (LOX).

Open Access – Open Data

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Publication: Our new paper is out in EMBO Reports

Thomas R. Cox, Sep 2015

I’m pleased to announce that our recent paper on Cancer-Associated-Fibroblasts (CAFs) in cancer has just been published in the Journal EMBO Reports titled “Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

In this paper we show that chronic hypoxia (lack of oxygen) within primary tumours leads to a deactivation of cancer associated fibroblasts. Continue reading

Altmetric score nears 200 in the first 7 days after publication

Thomas R. Cox, Jun 2015

Soaring Altmetrics

Our recent paper “The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase published in Nature last week has soared to 175 in the first 7 days.

Altmetrics hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Altmetrics of our paper as of 18:00 CET 03/07/15 – 7 days post publication

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Sheffield Live! Vimeo on our breast cancer breakthrough

Thomas R. Cox, Jun 2015

Local research into secondary breast cancer makes major breakthrough

Sheffield Live has run a short video piece on the recent ground breaking research into the prevention of secondary breast cancer which was conducted between Copenhagen University and Sheffield University.

“The pioneering research could lead to a better prognosis for cancer patients in the longer term.”

Newsy (news with the why) YouTube highlight

Thomas R. Cox, May 2015

Osteoporosis Drug Brings New Hope To Breast Cancer Treatment

Newsy (news with the why) has run a short video piece on their Science YouTube channel on our recent Nature Paper.

Katherine Biek from Newsy gives her perspective and an overview of our findings including the importance of our work in the treatment of breast cancer patients

Original Paper –
Newsy Science YouTube Channel

@Newsy, @KatherineBiek

Television highlight on Danish DR1

Thomas R. Cox, May 2015

Breakthrough for breast cancer patients led by Danish researchers

DR1, Denmarks principal channel for news and current affairs has run a short piece on our work which was recently published in Nature and the implications of our work for the treatment of breast cancer patients.

The coverage (shown below, aired on 29th May 2015 as part of the 18:30 News)

Link to Original Paper*
Link to Original blog post
Link to DR1

*For those readers without access to the full article, please contact me directly for a copy