Thomas R. Cox, July 2017
I was recently invited to chat with Norman Swan on ABC Radio National’s Health report about some of the recent work we have been doing on the Extracellular Matrix in cancer.
The extracellular matrix or the matrix is the web- or mesh-like structure that encases the cells in the tissues and organs of our body.
Image: Mayorca-Guiliani AE, Madsen CD, Cox TR et al. Nature Medicine (2017)
We recently developed a new technique which dissolves the cells from tumours to leave behind this matrix, allowing us to study it in unprecedented detail – and we discuss the potential of these research outcomes. Continue reading
Thomas R. Cox, Jun 2017
“We’re seeing things we’ve never seen before”: groundbreaking new technique sheds light on the ‘matrix’ surrounding our cells
Our most recent research has just been published in Nature Medicine.
In our paper we describe a new and intuitive new way to dissolve cells from tissues, leaving behind the extracellular matrix (ECM) or ‘matrix’.
The matrix is made up of 100’s of differing building blocks and surrounds the cells in our body. It is incredibly important in the progression and spread of cancer – but up until now it has been notoriously difficult to study in detail.
‘ISDoT’ mammary glad during lactation stained for the extracellular matrix (ECM) molecule Collagen IV
Thomas R. Cox, May 2017
Our new protocol on shear rheology of tumour tissues to measure tumour stiffness has just been published in bio-protocol
Thomas R. Cox, Feb 2017
Our new paper on the pre-clinical testing of two novel potential anti-cancer drugs in breast cancer has just been published in Oncotarget.
Thomas R. Cox, Dec 2017
We’re delighted to announce the we have been awarded a New Investigator Project Grant from the National Health and Medical Research Council (NHMRC).
The grant will support a project investigating how targeting tumour tissue stiffness can increase the efficacy of currently approved therapies in breast and colon cancer. Continue reading
Thomas R. Cox, Oct 2016
Our new article as part of a special issue of the Journal of Bone Oncology focusing on The role of the microenvironment in bone metastasis is now out:
Thomas R. Cox, Nov 2015
Kræfts evne til at sprede sig er en af de største udfordringer i bekæmpelsen af sygdommen. Har kræften spredt sig, bliver den nemlig meget sværere at få has på. Brystkræft, som årligt rammer næsten 4.900 danske kvinder, er blandt de kræftformer, som ofte spreder sig.
Nanna Bisbjerg fra Rask magasinet forsøger at forstå spredningen af kræft og har talt med Janine Erler og hendes team på Biotech Research and Innovation Centre (BRIC) på Københavns Universitet (KU) om fremtiden og hendes seneste forskning på området.
Den online version (kun på dansk) af artiklen kan findes i denne måneds Rask Magasinet her
Alternativt kan downloade en .pdf kopi af artiklen her
27% af alle kræfttilfælde blandt kvinder er brystkræft, hvilket svarer til at 13 kvinder hver dag får diagnosen. Hvis brystkræft spreder sig, sker det typisk til lunger, lever og knogler. Screening betyder heldigvis, at de fleste tilfælde opdages tidligt. (27% of all cancers among women are breast cancer, this means that 13 women are diagnosed every day. If breast cancer spreads, it typically goes to the lungs, liver and bone. With screening, fortunately, most cases are detected early)
Thomas R. Cox, Nov 2015
As part of our recent Nature paper (see previous post here) we sought to catalogue all of the different proteins secreted by breast cancer cells (the secretome) under conditions of hypoxia (low oxygen). Hypoxia is a common feature of most solid tumours and is very important in determining how cancer cells behave. Our hypothesis was that the breast cancer secretome changes under hypoxic conditions and that these changes were important in determining the how a patient’s tumour spreads around the body.
To create this catalogue, we performed Mass Spectrometry, a powerful analytical chemistry technique which allows us to both indentify and quantify proteins in a given sample. By creating a list of all the proteins present in the secretome of breast cancer cells, we were able to identify important proteins which may be responsible for determining how and where breast cancer spreads. In our paper we chose to focus specifically on one of these identified secreted proteins called Lysyl Oxidase (LOX).
Open Access – Open Data
Thomas R. Cox, Sep 2015
I’m pleased to announce that our recent paper on Cancer-Associated-Fibroblasts (CAFs) in cancer has just been published in the Journal EMBO Reports titled “Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.“
Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
In this paper we show that chronic hypoxia (lack of oxygen) within primary tumours leads to a deactivation of cancer associated fibroblasts. Continue reading