Thomas R. Cox, Apr 2018
Charting the unexplored extracellular matrix in cancer
Our new review on the recent advances in mapping the extracellular matrix in cancer has just been published in the International Journal of Experimental Pathology.
Composed of hundreds of different building blocks, the extracellular matrix (ECM) makes up the complex, highly cross‐linked, three‐dimensional (3D) network of macromolecules (proteins, glycoproteins and its subgroup of proteoglycans, polysaccharides (glycosaminoglycans), elastins and carbohydrates) that surround cells. It is essential to correct organisation and function of all tissues and organs, yet we know remarkably little about the assembly and organisation of these supramolecular structures of the ECM. In this review we discuss some of the recent advances and technologies that are helping us delve deeper into the matrix and further our understanding of the impact that dysregulated ECM has in diseases such as cancer.
Extracellular matrix building blocks
Thomas R. Cox, Jan 2018
Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Our new review on the how hypoxia is important in cancer-associated bone disease has just been published in Calcified Tissue International.
What is Hypoxia and why is it important in cancer?
Thomas R. Cox, Dec 2017
Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology
Our new paper on alternative collagen sources for 3D organotypic cultures for use as pre-clinical models is now out in Scientific Reports
Cellular interactions with the extracellular matrix (ECM) occur in a three-dimensional (3D) context and this essential aspect of the tumour microenvironment can lead to altered sensitivity to therapeutics and even act as a barrier to their delivery. This key feature is often overlooked in pre-clinical studies and is likely one of the central factors contributing to the high attrition rates of lead compounds within the pharmaceutical industry. This organotypic platform allows assessment of lead compounds in both the stromal compartment or in a 3D co-culture setting using large scale collagen preparations from alternative sources.
Thomas R. Cox, Jun 2017
“We’re seeing things we’ve never seen before”: groundbreaking new technique sheds light on the ‘matrix’ surrounding our cells
Our most recent research has just been published in Nature Medicine.
In our paper we describe a new and intuitive new way to dissolve cells from tissues, leaving behind the extracellular matrix (ECM) or ‘matrix’.
The matrix is made up of 100’s of differing building blocks and surrounds the cells in our body. It is incredibly important in the progression and spread of cancer – but up until now it has been notoriously difficult to study in detail.
Image: Mayorca-Guiliani AE, Madsen CD, Cox TR et al. Nature Medicine (2017)
Thomas R. Cox, May 2017
Our new protocol on shear rheology of tumour tissues to measure tumour stiffness has just been published in bio-protocol
Thomas R. Cox, Apr 2017
ROCK-ing pancreatic cancer to the core
Our new paper on short-term pulsed treatment, or ‘priming’ as a treatment strategy to boost chemotherapy has just been published in Science Translational Medicine.
The research, spearheaded by Dr. Paul Timpson and Dr. Marina Pajic here at the Garvan Institute of Medical Research in Sydney, has uncovered a promising new approach to treating pancreatic cancer. By targeting the tissue surrounding the tumour to make it ‘softer’, it leads to tumours being more responsive to chemotherapy.
Thomas R. Cox, Mar 2017
Pre-metastatic niches: organ-specific homes for metastases
Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.
What is the pre-metastatic niche (PMN)?
Thomas R. Cox, Feb 2017
Our new paper on the pre-clinical testing of two novel potential anti-cancer drugs in breast cancer has just been published in Oncotarget.
Thomas R. Cox, Jan 2017
Our new protocol on in vitro shear rheology of cell-embedded hydrogels has just been published in bio-protocol
Bio-protocol (ISSN: 2331-8325) is a peer-viewed e-journal established in 2011 by a group of Stanford researchers. Their mission is to make life science research more efficient and reproducible by curating and hosting high quality, open access, life science protocols.
Thomas R. Cox, May 2016
In collaboration with the department of oncology and department of clinical and experimental medicine at Linköping University in Sweden, we have just published a new paper looking at the importance of lysyl oxidase (LOX) in rectal cancer patients.