Category Archives: Articles

Publication: Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

 

Thomas R. Cox, Dec 2017

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

Our new paper on alternative collagen sources for 3D organotypic cultures for use as pre-clinical models is now out in Scientific Reports

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Cellular interactions with the extracellular matrix (ECM) occur in a three-dimensional (3D) context and this essential aspect of the tumour microenvironment can lead to altered sensitivity to therapeutics and even act as a barrier to their delivery. This key feature is often overlooked in pre-clinical studies and is likely one of the central factors contributing to the high attrition rates of lead compounds within the pharmaceutical industry. This organotypic platform allows assessment of lead compounds in both the stromal compartment or in a 3D co-culture setting using large scale collagen preparations from alternative sources.

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Publication: Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

 

Thomas R. Cox, Nov 2017

Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

Our new review on the how hypoxia is important in cancer-associated bone disease has just been published in Calcified Tissue International.

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What is Hypoxia and why is it important in cancer?

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Publication: ISDoT – in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

Thomas R. Cox, Jun 2017

“We’re seeing things we’ve never seen before”: groundbreaking new technique sheds light on the ‘matrix’ surrounding our cells

Our most recent research  has just been published in Nature Medicine.

In our  paper we describe a new and intuitive new way to dissolve cells from tissues, leaving behind the extracellular matrix (ECM) or ‘matrix’.

The matrix is made up of 100’s of differing building blocks and surrounds the cells in our body. It is incredibly important in the progression and spread of cancer – but up until now it has been notoriously difficult to study in detail.

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‘ISDoT’ mammary gland during lactation stained for the extracellular matrix (ECM) molecule Collagen IV

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Publication: Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

Thomas R. Cox, Apr 2017

ROCK-ing pancreatic cancer to the core

Our new paper on short-term pulsed treatment, or ‘priming’ as a treatment strategy to boost chemotherapy has just been published in Science Translational Medicine.

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STM Front Cover Vol 9 Issue 384 (Image: Timpson Laboratory, Garvan Institute)

 

The research, spearheaded by Dr. Paul Timpson and Dr. Marina Pajic here at the Garvan Institute of Medical Research in Sydney, has uncovered a promising new approach to treating pancreatic cancer. By targeting the tissue surrounding the tumour to make it ‘softer’, it leads to tumours being more responsive to chemotherapy.

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Publication: Pre-metastatic niches: organ-specific homes for metastases

Thomas R. Cox, Mar 2017

Pre-metastatic niches: organ-specific homes for metastases

Our new review on the importance of the pre-metastatic niche (PMN) in cancer has just been published in Nature Reviews Cancer. It summarises the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.

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What is the pre-metastatic niche (PMN)?

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Publication: Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro

Thomas R. Cox, Jan 2017

Our new protocol on in vitro shear rheology of cell-embedded hydrogels has just been published in bio-protocol

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Bio-protocol (ISSN: 2331-8325) is a peer-viewed e-journal established in 2011 by a group of Stanford researchers. Their mission is to make life science research more efficient and reproducible by curating and hosting high quality, open access, life science protocols.

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Publication: The importance of Lysyl Oxidase (LOX) in Rectal Cancer

Thomas R. Cox, May 2016

In collaboration with the department of oncology and department of clinical and experimental medicine at Linköping University in Sweden, we have just published a new paper looking at the importance of lysyl oxidase (LOX) in rectal cancer patients.

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Lysyl oxidase immunohistochemistry in rectal cancer samples

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Publication: Digital ‘Rosetta Stone’ able to decipher how genetic mutations rewire signalling in cancer cells

Thomas R. Cox, Sep 2015

Linding Lab publishes back-to-back papers in Cell explaining how genetic cancer mutations systematically attack the networks controlling human cells

Today Professor Rune Linding at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen (UCPH) along with collaborators at BRIC UCPH, Yale, University of Zurich (UZH), University of Rome and University of Tottori, have published back-to-back papers in Cell unravelling how disease mutations target and damage the protein signalling networks within human cells.

doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057

doi:10.1016/j.cell.2015.08.056 and doi:10.1016/j.cell.2015.08.057

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