About The Lab

Targetting the Extracellular Matrix in Cancer Metastasis

The Matrix and Metastasis Lab is based at the Garvan Institute of Medical Research Kinghorn Cancer Centre in Sydney, Australia.

Our research focuses on how ECM remodelling influences cancer progression, therapy response, and metastatic dissemination in solid tumours. In particular we work on the role of post-translational modification of the ECM, including Lysyl Oxidase (LOX) and Lysyl Oxidase Like (LOXL) family members. Our work looks at the importance of these changes in regulating both the biochemical and biomechanical properties of the ECM during fibrosis, cancer progression and metastasis. These ECM changes lead to significant alterations in cellular response to drugs, and we work to understand how we can use dual therapy approaches to improve drug efficacy. Our research includes multidisciplinary, international collaborative projects working with biologists, physicists, engineers and clinicians to study disease progression at a systems biology level.

Click here to read more about Thomas’ career

Lab Members

Matrix & Metastasis - Joanna Skhinas Joanna Skhinas
Research Assistant

“I’m interested in cancer biology, in particular the interactions between cancer cells and the surrounding extracellular matrix, and the ECMs role in metastasis. I’m also interested in studying these interactions through the use of 2D and 3D in vitro and in vivo models.”

Research Interests

Extracellular Matrix
Cellular Microenvironment
Biomechanics
Lysyl Oxidases
Targeted therapies
Kinase signalling
Systems Biology
Network Medicine
Proteomics
Breast Cancer
Colorectal Cancer
Cancer Metastasis

Publications

See here for a full publication list

Funding

Work in the Matrix and Metastasis Lab is supported by the following funding:

NHMRC Logo 1 SGK logo 2017
Sydney Catalyst