Publication: Recent advances in understanding the complexities of metastasis

Thomas R. Cox, Sep 2018

Recent advances in understanding the complexities of metastasis

We are excited to announce that our recent F1000 Faculty Invited Review on “Recent advances in understanding the complexities of metastasis” has just been published in F1000Research.

The Metastatic Cascade in Cancer

Abstract

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of events, which is influenced by the intrinsic cellular mutational burden of cancer cells and the numerous bidirectional interactions between malignant and non-malignant cells and fine-tuned by the various extrinsic cues of the extracellular matrix. In cancer biology, metastasis as a process is one of the most technically challenging aspects of cancer biology to study. As a result, new platforms and technologies are continually being developed to better understand this process. In this review, we discuss some of the recent advances in metastasis and how the information gleaned is re-shaping our understanding of metastatic dissemination.

Links

View abstract on PubMed
Read the full article on the F1000 website (Open Access)
Download a PDF copy
Download Hi-Res version of Figure 1

Citation

Chitty et al. Recent advances in understanding the complexities of metastasis
F1000Res (2018) | doi: 10.12688/f1000research.15064.2

Key Words

Metastasis, Cancer, Cancer Therapy, Extracellular Matrix, Tumour Stroma, Microenvironment, Intravital Imaging, Mouse Models, Biosensors, Circulating Tumour Cells, Disseminated Tumour Cells, Dormancy, Colonisation, Intravasation, Extravasation, Invasion, Migration

Funding

The authors are supported by the National Health and Medical Research Council of Australia, Susan G. Komen for the Cure (CCR17483294), National Breast Cancer Foundation, Cancer Institute NSW, the Australian Research Council, a Len Ainsworth Pancreatic Cancer Fellowship, Cancer Council NSW, St Vincent’s Clinic Foundation, Sydney Catalyst and Tour de Cure. This project was made possible by an Avner Pancreatic Cancer Foundation grant.