Thomas R. Cox, Dec 2017
We’re delighted to announce the we have been awarded a New Investigator Project Grant from the National Health and Medical Research Council (NHMRC).
The grant will support a project investigating how targeting tumour tissue stiffness can increase the efficacy of currently approved therapies in breast and colon cancer.
Tissue stiffness is critically important in driving cancer cell proliferation. Increased breast tissue density (stiffening) is one of the single largest risk factors for developing breast cancer. Our previous work has shown that changes in tissue stiffness modulate critical intracellular signalling pathways to drive aggressive cell behaviour in breast and colorectal cancer. Yet there are few studies into how tissue stiffness modulates the response of cancer cells to targeted therapies. This project will focus on understanding and developing new approaches to targeting tumour tissue stiffness to improve the efficacy of already approved cancer therapies.