Publication: New Perspective in Disease Models and Mechanisms

Thomas R. Cox, Mar 2011

My recent perspective on the importance of remodelling and homeostasis in the extracellular matrix and the implications for fibrotic diseases and cancer has just been published in the journal Disease Models and Mechanisms.

The role of LOX in tumor progression.

Image: Disease Models and Mechanisms; The role of LOX in tumor progression.

In this perspective we discuss the importance of the extracellular matrix (ECM) and it’s role in maintaining the tissues and organs within the body. Multiple control mechanisms work together to make sure that the delicate balances within tissues remain intact. However, in diseases such as tissue fibrosis and cancer, these balances are upset, often significantly which leads to dangerous changes in organs that propagate the disease. Understanding what leads to this loss of control and how the outcomes affect disease progression will be critical to developing therapies to prevent such devastating diseases.


View article on Disease Models and Mechanisms homepage
View abstract on PubMed


Cox TR and Erler JT. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer.
Disease Models and Mechanisms, March 2011, vol. 4 no. 2 165-178 | doi: 10.1242/dmm.004077